Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2281772..2283401 Replicon chromosome
Accession NZ_CP009781
Organism Yersinia aldovae 670-83

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AT01_RS10420 Protein ID WP_042547108.1
Coordinates 2282073..2283401 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AT01_RS10415 Protein ID WP_042547107.1
Coordinates 2281772..2282071 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT01_RS10400 2277268..2278917 - 1650 WP_004704764.1 Na+/H+ antiporter -
AT01_RS10405 2279133..2280500 - 1368 WP_042547105.1 NCS2 family permease -
AT01_RS10410 2280863..2281531 - 669 WP_042547106.1 glutathione S-transferase -
AT01_RS10415 2281772..2282071 + 300 WP_042547107.1 helix-turn-helix transcriptional regulator Antitoxin
AT01_RS10420 2282073..2283401 + 1329 WP_042547108.1 type II toxin-antitoxin system HipA family toxin Toxin
AT01_RS10425 2283478..2284029 - 552 WP_042547109.1 single-stranded DNA-binding protein -
AT01_RS10430 2284556..2287387 + 2832 WP_042547110.1 excinuclease ABC subunit UvrA -
AT01_RS10435 2287446..2287799 - 354 WP_004704757.1 MmcQ/YjbR family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49833.66 Da        Isoelectric Point: 6.5010

>T49733 WP_042547108.1 NZ_CP009781:2282073-2283401 [Yersinia aldovae 670-83]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYSQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSISPFDLLVELGRDCVGAIQLLADDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVHPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVARCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPGITTIMEILSGSDNASEDRNAFFKTQIIFWLLAATDGHAKNFS
ITHLPGNHYHLTPLYDVLSTHPIIGSGRYQIASQKAKLAMAVRGSENYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLADNILAGLDRQCKKIAAMP

Download         Length: 1329 bp

>T49733 NZ_CP009781:2282073-2283401 [Yersinia aldovae 670-83]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAGCATGTTGGCTATTGGGAAAAAAATCGAGGTGAAGA
ATCACTGGTTTATTCCCAAGAATGGTTAGCAAACGAACAAGGTCGCCCGCTATCGTTATCATTGCCTTTCACTGCCAATA
ATCAGGTTTATAGAGGTAATATTGTCCGGGACTATTTTGATAATTTATTGCCCGATAGCGATGATATCCGGCGGCGGCTG
GCAACTAAATATCACGCTGACAGCATCAGCCCTTTTGATCTACTCGTTGAATTAGGGAGAGATTGTGTCGGTGCAATACA
ATTGCTGGCTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TCCTACGAAACTCATTATCTGACAATGCATTTGTGCACCCTGAACACGATGAGGATCTCAGATTATCTATTGCTGGAGCA
CAAGAAAAAACAGCCCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTGGGCAGCACTCCCACCACCCATATATTCAA
ACTTCCGTTGGGTTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTGCCGGTTGCCCGTTGTGAAATTGGCCAGTTTGAAGATCAAAAGGCATTGATTGTTGAGCGTTTT
GACCGACGGTTATCGCGTGACAAGAGTTGGATCGTCAGATTGCCGCAAGAAGATATGTGTCAGGCCACAGGGACTTCCCC
CTTAAAAAAATATCAAATGGATGGTGGCCCCGGTATTACCACCATAATGGAGATTTTGAGTGGTTCGGATAATGCCAGTG
AGGACAGAAATGCTTTCTTTAAAACGCAGATTATTTTCTGGTTATTGGCCGCAACTGATGGACATGCAAAAAACTTTAGC
ATTACGCATTTGCCTGGGAATCATTATCACCTCACCCCGCTTTACGATGTGCTATCGACCCACCCGATTATTGGTTCGGG
CCGTTATCAAATTGCATCCCAAAAAGCCAAGTTAGCGATGGCGGTGAGAGGGAGTGAAAATTACTATTTGATTAACCAGA
TTCAACGCCGTCATTGGCGAAAACAGGCAGAATTTGTTGGACTAGGAGCGATTCAAGCTGACACTATTATTGATGAAATA
ATTGCCGCAACCCCACGGGTTATCACACAAGTACAAGCCCAACTTCCGGCTAATTTTCCTGCTGACTTAGCAGATAATAT
CCTTGCAGGCCTTGATCGACAGTGCAAAAAAATAGCTGCAATGCCTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11123.76 Da        Isoelectric Point: 8.4635

>AT49733 WP_042547107.1 NZ_CP009781:2281772-2282071 [Yersinia aldovae 670-83]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPASASVERLFKVLQLLDVELILGEKKNANSYPSK
THQPEQSQTIDLPSKQEDW

Download         Length: 300 bp

>AT49733 NZ_CP009781:2281772-2282071 [Yersinia aldovae 670-83]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCGACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGTATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCGCCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATCCTTGGTGAGAAAAAAAACGCCAACTCGTATCCCAGTAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References