Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1514469..1515088 Replicon chromosome
Accession NZ_CP009781
Organism Yersinia aldovae 670-83

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag AT01_RS07070 Protein ID WP_002208622.1
Coordinates 1514885..1515088 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9UHU0
Locus tag AT01_RS07065 Protein ID WP_004703332.1
Coordinates 1514469..1514837 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT01_RS07035 1510335..1510595 + 261 WP_004703318.1 type B 50S ribosomal protein L31 -
AT01_RS07040 1510611..1510754 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
AT01_RS07045 1510883..1511761 - 879 WP_004703326.1 metal ABC transporter substrate-binding protein -
AT01_RS07050 1511790..1512647 - 858 WP_042546622.1 metal ABC transporter permease -
AT01_RS07055 1512644..1513381 - 738 WP_042548537.1 ABC transporter ATP-binding protein -
AT01_RS07060 1513957..1514310 + 354 WP_042546623.1 hypothetical protein -
AT01_RS07065 1514469..1514837 + 369 WP_004703332.1 Hha toxicity modulator TomB Antitoxin
AT01_RS07070 1514885..1515088 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
AT01_RS07075 1515979..1516359 + 381 WP_082039561.1 MGMT family protein -
AT01_RS07080 1516415..1516948 - 534 WP_042546625.1 YbaY family lipoprotein -
AT01_RS07085 1517203..1518063 + 861 WP_042546626.1 acyl-CoA thioesterase II -
AT01_RS07090 1518142..1519431 - 1290 WP_042548538.1 ammonium transporter AmtB -
AT01_RS07095 1519471..1519809 - 339 WP_042546627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49730 WP_002208622.1 NZ_CP009781:1514885-1515088 [Yersinia aldovae 670-83]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49730 NZ_CP009781:1514885-1515088 [Yersinia aldovae 670-83]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACGCTGGAACGTGTAATTGAAAAAAATAA
GTATGAGCTTTCTGATGATGAGTTGGAATTGTTTTACTCTGCTGCGGACCACCGTCTGGCTGAGCTAACAATGAATAAGC
TTTATGATAAAATCCCACCTACTGTCTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.96 Da        Isoelectric Point: 4.4306

>AT49730 WP_004703332.1 NZ_CP009781:1514469-1514837 [Yersinia aldovae 670-83]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELHRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT49730 NZ_CP009781:1514469-1514837 [Yersinia aldovae 670-83]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAGTTGAAATTTTTATGCGAAAACCTGTATGATGAAGGCATTGC
AACCCTTGGCGATAGCCATCATGGCTGGGTAAATGATCCTACATCTGCGGTAAACCTTCAGCTTAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCAGATGACGGCGATTTGTCAGAGTTAGTGGAAGAATATTTA
GACGATACTTATACTCTGTTTAGTAGTTATGGCATCAATGATCCCGAATTGCACCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UHU0

References