Detailed information of TA system TA049720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 341073..342077
• Replicon: chromosome
• Accession: NZ_CP009781
• Organism: Yersinia aldovae 670-83

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9T619
• Locus tag: AT01_RS01645
• Protein ID: WP_004702144.1
• Coordinates: 341073..341531 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AT01_RS01650
• Protein ID: WP_042545815.1
• Coordinates: 341631..342077 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT01_RS01615	336918..337583	+	666	WP_042545810.1	phage shock protein PspA	-
AT01_RS01620	337691..337918	+	228	WP_042545811.1	envelope stress response membrane protein PspB	-
AT01_RS01625	337918..338292	+	375	WP_004702154.1	envelope stress response membrane protein PspC	-
AT01_RS01630	338379..338621	+	243	WP_042545812.1	phage shock protein PspD	-
AT01_RS01635	338602..339999	+	1398	WP_042545813.1	YcjX family protein	-
AT01_RS01640	339996..341057	+	1062	WP_042545814.1	YcjF family protein	-
AT01_RS01645	341073..341531	-	459	WP_004702144.1	RES family NAD+ phosphorylase	Toxin
AT01_RS01650	341631..342077	-	447	WP_042545815.1	DUF2384 domain-containing protein	Antitoxin
AT01_RS01655	342395..343972	+	1578	WP_042545816.1	transcriptional regulator TyrR	-
AT01_RS01660	344057..344560	-	504	WP_042545817.1	thiol peroxidase	-
AT01_RS01665	344714..345685	+	972	WP_042545818.1	L-Ala-D/L-Glu epimerase	-
AT01_RS01670	345682..346383	-	702	WP_042545819.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17181.73 Da
• Isoelectric Point: 6.2149

>T49720 WP_004702144.1 NZ_CP009781:c341531-341073 [Yersinia aldovae 670-83]
MMLYRIVMRRYLASTWTGYGAEMYGGRWNHKGHAAIYLASSISLAMLETLVHIHDSTTLSEFELFQIEINDGSIMLLQPQ
DWPSEWRSDPAPVAAMDVGTEWLKSESSVGLLVPSTLVPSENNMLVNPHHKDFQGCLKSVKPLSFAFDPRLR

Nucleotide

• Length: 459 bp

>T49720 NZ_CP009781:c341531-341073 [Yersinia aldovae 670-83]
ATGATGCTCTACCGCATCGTAATGCGCCGTTATCTCGCCTCAACCTGGACCGGTTATGGTGCCGAAATGTACGGTGGCCG
TTGGAATCATAAAGGCCATGCTGCTATCTACTTGGCCAGCAGCATATCACTGGCGATGCTGGAAACATTGGTACATATTC
ACGACAGCACTACGCTCAGTGAATTTGAGTTATTTCAGATTGAAATTAATGACGGCAGCATTATGCTGCTGCAACCGCAA
GATTGGCCGTCAGAGTGGCGAAGTGATCCGGCACCGGTCGCAGCAATGGACGTTGGCACCGAGTGGCTGAAATCAGAGTC
ATCTGTTGGATTACTGGTTCCATCCACCCTGGTGCCATCAGAGAATAATATGTTGGTTAACCCGCATCACAAAGACTTTC
AGGGTTGTCTAAAAAGCGTCAAGCCGCTCTCTTTTGCCTTTGACCCGCGGCTAAGATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16297.71 Da
• Isoelectric Point: 9.1260

>AT49720 WP_042545815.1 NZ_CP009781:c342077-341631 [Yersinia aldovae 670-83]
MRAYHPAPATKTGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDATVDLFSGDKGKAITWMSTPIKGLGHRTPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT49720 NZ_CP009781:c342077-341631 [Yersinia aldovae 670-83]
ATGAGAGCATATCATCCAGCCCCAGCGACCAAAACAGGGGCGCTGTGGCGTGAAATTGGCCTGCCGGCCAGTCGCGGCAC
TGTGCTGGTAGACAGTATCAAGCTAGGATTTTCTGTTGATGTCATCGACAGTATTCATTTATGGGCGTCAATGCCTAAAT
CCGAGATATTACGTGCCACGGGGATCCCCAGCCGTAGTCTGACTCGCCGCCGTACCCATGATGGCCGTTTTACCCCGGAA
GAGAGTGAGCGAATTGCGCGTTTTGTGCGTGTCATGGATGCCACTGTTGACCTCTTTAGCGGAGATAAAGGCAAGGCAAT
CACCTGGATGTCCACGCCTATCAAAGGCTTGGGCCACAGAACCCCTGACTCCCTGTTGGAAACGGAAACCGGCGCACTGG
AAGTCTGTGATTTGATTGGCCGACTGGAACACGGCGTGTTCTCGTAA

Structures

Toxin

• AlphaFold DB: A0A0T9T619