Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 3808880..3809636 | Replicon | chromosome |
| Accession | NZ_CP009780 | ||
| Organism | Yersinia pseudotuberculosis PB1/+ | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A3G5KDU1 |
| Locus tag | BZ16_RS17510 | Protein ID | WP_032467110.1 |
| Coordinates | 3808880..3809248 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | Q664A5 |
| Locus tag | BZ16_RS17515 | Protein ID | WP_011193303.1 |
| Coordinates | 3809301..3809636 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BZ16_RS17480 | 3803960..3804967 | + | 1008 | WP_011193296.1 | iron chelate uptake ABC transporter family permease subunit | - |
| BZ16_RS17485 | 3804964..3805722 | + | 759 | WP_011193297.1 | ABC transporter ATP-binding protein | - |
| BZ16_RS17490 | 3805719..3806219 | - | 501 | WP_002214364.1 | virulence RhuM family protein | - |
| BZ16_RS17495 | 3806161..3806487 | - | 327 | WP_011193298.1 | hypothetical protein | - |
| BZ16_RS17500 | 3806510..3806917 | - | 408 | WP_011193299.1 | hypothetical protein | - |
| BZ16_RS22675 | 3807152..3807424 | - | 273 | WP_011193300.1 | Arm DNA-binding domain-containing protein | - |
| BZ16_RS17505 | 3807799..3808653 | - | 855 | WP_032467109.1 | DUF4942 domain-containing protein | - |
| BZ16_RS17510 | 3808880..3809248 | - | 369 | WP_032467110.1 | TA system toxin CbtA family protein | Toxin |
| BZ16_RS17515 | 3809301..3809636 | - | 336 | WP_011193303.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BZ16_RS17520 | 3809648..3810127 | - | 480 | WP_011193304.1 | hypothetical protein | - |
| BZ16_RS17525 | 3810310..3810930 | - | 621 | WP_011193305.1 | hypothetical protein | - |
| BZ16_RS17530 | 3810958..3811512 | - | 555 | WP_011193306.1 | hypothetical protein | - |
| BZ16_RS17535 | 3811760..3812437 | - | 678 | WP_041175577.1 | hypothetical protein | - |
| BZ16_RS17540 | 3812485..3812778 | - | 294 | Protein_3272 | ATP-binding protein | - |
| BZ16_RS17545 | 3813443..3813679 | + | 237 | Protein_3273 | inovirus Gp2 family protein | - |
| BZ16_RS17550 | 3813745..3814524 | - | 780 | WP_001297096.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3798403..3823543 | 25140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13723.81 Da Isoelectric Point: 6.4530
>T49719 WP_032467110.1 NZ_CP009780:c3809248-3808880 [Yersinia pseudotuberculosis PB1/+]
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
Download Length: 369 bp
>T49719 NZ_CP009780:c3809248-3808880 [Yersinia pseudotuberculosis PB1/+]
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12452.06 Da Isoelectric Point: 6.0555
>AT49719 WP_011193303.1 NZ_CP009780:c3809636-3809301 [Yersinia pseudotuberculosis PB1/+]
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
Download Length: 336 bp
>AT49719 NZ_CP009780:c3809636-3809301 [Yersinia pseudotuberculosis PB1/+]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G5KDU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q664A5 |