Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2888334..2889006 Replicon chromosome
Accession NZ_CP009780
Organism Yersinia pseudotuberculosis PB1/+

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag BZ16_RS13590 Protein ID WP_012104676.1
Coordinates 2888334..2888759 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag BZ16_RS13595 Protein ID WP_002209939.1
Coordinates 2888740..2889006 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ16_RS13570 2884012..2884530 + 519 WP_002209934.1 flavodoxin FldB -
BZ16_RS13575 2884615..2886072 - 1458 WP_032466588.1 cell envelope integrity protein CreD -
BZ16_RS13580 2886193..2887611 - 1419 WP_012413923.1 two-component system sensor histidine kinase CreC -
BZ16_RS13585 2887636..2888334 - 699 WP_002209937.1 two-component system response regulator CreB -
BZ16_RS13590 2888334..2888759 - 426 WP_012104676.1 protein YgfX Toxin
BZ16_RS13595 2888740..2889006 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
BZ16_RS13600 2889323..2890315 + 993 WP_012413924.1 tRNA-modifying protein YgfZ -
BZ16_RS13605 2890388..2890885 - 498 WP_002209941.1 DUF2165 family protein -
BZ16_RS13610 2891160..2891861 - 702 WP_012413925.1 hemolysin III family protein -
BZ16_RS13615 2892063..2893166 - 1104 WP_012413926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T49718 WP_012104676.1 NZ_CP009780:c2888759-2888334 [Yersinia pseudotuberculosis PB1/+]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T49718 NZ_CP009780:c2888759-2888334 [Yersinia pseudotuberculosis PB1/+]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCTATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT49718 WP_002209939.1 NZ_CP009780:c2889006-2888740 [Yersinia pseudotuberculosis PB1/+]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT49718 NZ_CP009780:c2889006-2888740 [Yersinia pseudotuberculosis PB1/+]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References