49666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4910777..4912362 Replicon chromosome
Accession NZ_CP009769
Organism Pectobacterium brasiliense strain BC1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NC16_RS22385 Protein ID WP_039502506.1
Coordinates 4911043..4912362 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NC16_RS22380 Protein ID WP_039498288.1
Coordinates 4910777..4911043 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC16_RS22355 4906409..4907911 - 1503 WP_039502513.1 MFS transporter -
NC16_RS22360 4908015..4908569 + 555 WP_039502511.1 TetR/AcrR family transcriptional regulator -
NC16_RS22365 4908619..4909029 - 411 WP_117589383.1 helix-turn-helix transcriptional regulator -
NC16_RS22370 4909157..4910008 + 852 WP_039498290.1 SDR family oxidoreductase -
NC16_RS22375 4910053..4910616 - 564 WP_052325986.1 hypothetical protein -
NC16_RS22380 4910777..4911043 + 267 WP_039498288.1 helix-turn-helix domain-containing protein Antitoxin
NC16_RS22385 4911043..4912362 + 1320 WP_039502506.1 type II toxin-antitoxin system HipA family toxin Toxin
NC16_RS22390 4912865..4913800 - 936 WP_039502504.1 retron St85 family RNA-directed DNA polymerase -
NC16_RS22395 4913800..4914762 - 963 WP_039502503.1 retron St85 family effector protein -
NC16_RS22850 4915087..4915572 - 486 Protein_4292 site-specific integrase -
NC16_RS22410 4915893..4917257 - 1365 WP_075278537.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49346.60 Da        Isoelectric Point: 6.6896

>T49666 WP_039502506.1 NZ_CP009769:4911043-4912362 [Pectobacterium brasiliense]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARYH
TDSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDRWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVYPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKMAMGLTGSRGKKYAIEQIFPRHFFQTAKVVGFARESMENILAEFAHTV
DTVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T49666 NZ_CP009769:4911043-4912362 [Pectobacterium brasiliense]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGGGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGATTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGCCCTATCAGG
GCGATGAAGTTTATAACTTTTTCGACAATCTGTTGCCGGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGTATCAT
ACGGATTCCACTCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGTGCGTTGCAATTAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATATAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGACTGGATATT
TGTCCGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATCTCTATCGCAGGTGCACAGGAAAAGACGGCG
TTGCTGTATCTGGATGATCGCTGGTGCCTGCCTCTCAATGCCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGTTTGCTCATTGCCAAGGCAT
TTGGGTTACCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGTTCGGTTTATCCAGAAAGGGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACAGATGGTCATGCGAAAAATTTTTCCCTGTTTATT
GAATCTGAGGGACGATATCGACTCACGCCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAGGCCAAAATGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGAC
ATTTTTTCCAGACGGCGAAGGTCGTTGGGTTTGCCAGAGAATCGATGGAAAACATTCTGGCGGAGTTTGCCCACACTGTT
GATACCGTCATGACGACTGTTGGAAGTCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9973.29 Da        Isoelectric Point: 9.7281

>AT49666 WP_039498288.1 NZ_CP009769:4910777-4911043 [Pectobacterium brasiliense]
MKITNSKQLSSYLKDVRITQKLSQVKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW

Download         Length: 267 bp

>AT49666 NZ_CP009769:4910777-4911043 [Pectobacterium brasiliense]
ATGAAGATCACCAACAGCAAGCAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGTGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGTTTCGAGCAACATCCTGATTCCACTAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAATTTAGAACTTACCGTTACGCCCAGGAATGTGGACACCACCAATAACGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References