Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1207188..1207813 Replicon chromosome
Accession NZ_CP009769
Organism Pectobacterium brasiliense strain BC1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag NC16_RS05480 Protein ID WP_005976087.1
Coordinates 1207188..1207391 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag NC16_RS05485 Protein ID WP_010282247.1
Coordinates 1207445..1207813 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC16_RS05450 1202522..1202860 + 339 WP_002208627.1 P-II family nitrogen regulator -
NC16_RS05455 1202900..1204186 + 1287 WP_014914537.1 ammonium transporter AmtB -
NC16_RS05460 1204326..1205189 - 864 WP_014914538.1 acyl-CoA thioesterase II -
NC16_RS05465 1205402..1205983 + 582 WP_014914539.1 YbaY family lipoprotein -
NC16_RS05470 1206003..1206323 - 321 WP_010282239.1 MGMT family protein -
NC16_RS05480 1207188..1207391 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
NC16_RS05485 1207445..1207813 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
NC16_RS05490 1208412..1208555 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
NC16_RS05495 1208573..1208821 - 249 WP_039274617.1 type B 50S ribosomal protein L31 -
NC16_RS05500 1209054..1212182 - 3129 WP_039466835.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T49658 WP_005976087.1 NZ_CP009769:c1207391-1207188 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T49658 NZ_CP009769:c1207391-1207188 [Pectobacterium brasiliense]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGCCTGGCAGAACTGACGATGAACAAAC
TCTACGACAAAGTCCCTACTGCAGTATGGCGATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT49658 WP_010282247.1 NZ_CP009769:c1207813-1207445 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT49658 NZ_CP009769:c1207813-1207445 [Pectobacterium brasiliense]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
GACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGATGCTGAACTACGGCGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACATCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References