Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 171644..172261 Replicon chromosome
Accession NZ_CP009769
Organism Pectobacterium brasiliense strain BC1

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag NC16_RS00780 Protein ID WP_010281507.1
Coordinates 172082..172261 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7T5QP09
Locus tag NC16_RS00775 Protein ID WP_010299285.1
Coordinates 171644..172054 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC16_RS00760 167524..168567 - 1044 WP_010281514.1 DNA-binding transcriptional regulator CytR -
NC16_RS00765 168876..171074 - 2199 WP_039474910.1 primosomal protein N' -
NC16_RS00770 171347..171562 + 216 WP_010281510.1 50S ribosomal protein L31 -
NC16_RS00775 171644..172054 - 411 WP_010299285.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NC16_RS00780 172082..172261 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
NC16_RS00785 172361..173371 - 1011 WP_075277762.1 iron ABC transporter permease -
NC16_RS00790 173368..174330 - 963 WP_075277763.1 ABC transporter substrate-binding protein -
NC16_RS00795 174340..175137 - 798 WP_040035359.1 ABC transporter ATP-binding protein -
NC16_RS00800 175372..175689 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
NC16_RS00805 175877..177037 + 1161 WP_039281157.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T49653 WP_010281507.1 NZ_CP009769:c172261-172082 [Pectobacterium brasiliense]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T49653 NZ_CP009769:c172261-172082 [Pectobacterium brasiliense]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCTAGCAAACCGGGGTTAGTCACCATCCCCCACCCTAAGAAAGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14549.41 Da        Isoelectric Point: 4.3391

>AT49653 WP_010299285.1 NZ_CP009769:c172054-171644 [Pectobacterium brasiliense]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT49653 NZ_CP009769:c172054-171644 [Pectobacterium brasiliense]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTAGCAAAAAACTCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACGCTGCCTAAGTCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A7T5QP09

References