Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 56221..56746 Replicon plasmid pFORC7
Accession NZ_CP009767
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain FORC_007

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag FORC7_RS00345 Protein ID WP_001159863.1
Coordinates 56441..56746 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag FORC7_RS00340 Protein ID WP_000813641.1
Coordinates 56221..56439 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC7_RS00315 51835..52221 + 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -
FORC7_RS23285 52274..52435 + 162 WP_015059604.1 hypothetical protein -
FORC7_RS00320 52762..53751 - 990 WP_000461382.1 RepB family plasmid replication initiator protein -
FORC7_RS24670 54245..54540 - 296 Protein_66 cytoplasmic protein -
FORC7_RS25435 54552..54980 + 429 Protein_67 hypothetical protein -
FORC7_RS00335 55024..55545 - 522 WP_077681952.1 hypothetical protein -
FORC7_RS00340 56221..56439 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FORC7_RS00345 56441..56746 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
FORC7_RS00350 56748..57038 + 291 WP_001266176.1 hypothetical protein -
FORC7_RS00355 57035..57556 + 522 WP_000198608.1 hypothetical protein -
FORC7_RS00360 57591..58373 + 783 WP_000082169.1 site-specific integrase -
FORC7_RS00365 58382..59047 + 666 Protein_74 EAL domain-containing protein -
FORC7_RS00370 59101..59805 - 705 WP_023327680.1 IS6-like element IS26 family transposase -
FORC7_RS00375 59871..60185 + 315 Protein_76 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101428 101428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T49650 WP_001159863.1 NZ_CP009767:56441-56746 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T49650 NZ_CP009767:56441-56746 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT49650 WP_000813641.1 NZ_CP009767:56221-56439 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT49650 NZ_CP009767:56221-56439 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References