Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1938830..1939358 Replicon chromosome
Accession NZ_CP009765
Organism Vibrio parahaemolyticus strain FORC_006

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag FORC6_RS09180 Protein ID WP_005377002.1
Coordinates 1939068..1939358 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag FORC6_RS09175 Protein ID WP_005377003.1
Coordinates 1938830..1939078 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC6_RS09150 1934053..1934643 - 591 WP_079740768.1 cold shock and DUF1294 domain-containing protein -
FORC6_RS09155 1934834..1935043 - 210 WP_045608932.1 DUF3955 domain-containing protein -
FORC6_RS24280 1935629..1935719 - 91 Protein_1764 DUF3265 domain-containing protein -
FORC6_RS26400 1935841..1936056 - 216 WP_172401954.1 hypothetical protein -
FORC6_RS24285 1936241..1936333 - 93 WP_005445734.1 DUF3265 domain-containing protein -
FORC6_RS09165 1936371..1937504 - 1134 WP_042764360.1 hypothetical protein -
FORC6_RS09170 1937501..1938001 - 501 WP_042764359.1 DUF4365 domain-containing protein -
FORC6_RS24290 1938687..1938755 - 69 WP_074531725.1 DUF3265 domain-containing protein -
FORC6_RS09175 1938830..1939078 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC6_RS09180 1939068..1939358 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC6_RS09185 1939484..1940110 - 627 WP_060657881.1 hypothetical protein -
FORC6_RS24295 1940155..1940245 - 91 Protein_1773 DUF3265 domain-containing protein -
FORC6_RS09190 1940268..1940717 - 450 WP_060657883.1 GyrI-like domain-containing protein -
FORC6_RS09195 1940861..1941649 - 789 WP_025506320.1 FRG domain-containing protein -
FORC6_RS09200 1941794..1942201 - 408 WP_005466276.1 OsmC family protein -
FORC6_RS24300 1942251..1942343 - 93 WP_079740769.1 DUF3265 domain-containing protein -
FORC6_RS09205 1942371..1942751 - 381 WP_060657885.1 nuclear transport factor 2 family protein -
FORC6_RS09210 1942907..1943236 - 330 WP_021448773.1 hypothetical protein -
FORC6_RS24305 1943272..1943364 - 93 WP_074546611.1 DUF3265 domain-containing protein -
FORC6_RS09215 1943399..1943800 - 402 WP_005433790.1 HIT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1823640..2013809 190169
- inside Integron - - 1824883..2012098 187215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T49649 WP_005377002.1 NZ_CP009765:1939068-1939358 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T49649 NZ_CP009765:1939068-1939358 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT49649 WP_005377003.1 NZ_CP009765:1938830-1939078 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT49649 NZ_CP009765:1938830-1939078 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References