Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1852120..1852667 Replicon chromosome
Accession NZ_CP009765
Organism Vibrio parahaemolyticus strain FORC_006

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FORC6_RS08615 Protein ID WP_025613283.1
Coordinates 1852120..1852422 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag FORC6_RS08620 Protein ID WP_005448240.1
Coordinates 1852410..1852667 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC6_RS26375 1847213..1847380 - 168 WP_001883086.1 DUF3265 domain-containing protein -
FORC6_RS08585 1847761..1848186 - 426 WP_025613242.1 N-acetyltransferase -
FORC6_RS08590 1848341..1848763 - 423 WP_025613243.1 hypothetical protein -
FORC6_RS08595 1848926..1849870 - 945 WP_025613244.1 D-2-hydroxyacid dehydrogenase family protein -
FORC6_RS23965 1849897..1849989 - 93 WP_079740743.1 DUF3265 domain-containing protein -
FORC6_RS08600 1850023..1850379 - 357 WP_020198239.1 hypothetical protein -
FORC6_RS08605 1850532..1851008 - 477 WP_180760184.1 DUF4145 domain-containing protein -
FORC6_RS08610 1851358..1851954 - 597 WP_060657808.1 methyltransferase domain-containing protein -
FORC6_RS23970 1851992..1852084 - 93 WP_079740744.1 DUF3265 domain-containing protein -
FORC6_RS08615 1852120..1852422 - 303 WP_025613283.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC6_RS08620 1852410..1852667 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC6_RS08625 1852867..1853217 - 351 WP_008077879.1 hypothetical protein -
FORC6_RS08630 1853363..1853824 - 462 WP_140053015.1 hypothetical protein -
FORC6_RS23975 1853853..1853945 - 93 WP_079740850.1 DUF3265 domain-containing protein -
FORC6_RS08635 1853968..1854435 - 468 WP_060657810.1 NUDIX domain-containing protein -
FORC6_RS08640 1854557..1855078 - 522 Protein_1624 GNAT family N-acetyltransferase -
FORC6_RS23980 1855109..1855186 - 78 WP_079740851.1 DUF3265 domain-containing protein -
FORC6_RS08645 1855220..1855726 - 507 Protein_1626 GNAT family N-acetyltransferase -
FORC6_RS08650 1855874..1856482 - 609 WP_025613305.1 pyridoxamine 5'-phosphate oxidase family protein -
FORC6_RS23985 1856518..1856673 - 156 WP_079740745.1 DUF3265 domain-containing protein -
FORC6_RS08655 1856663..1856968 - 306 WP_025613306.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1823640..2013809 190169
- inside Integron - - 1824883..2012098 187215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11641.51 Da        Isoelectric Point: 5.1765

>T49648 WP_025613283.1 NZ_CP009765:c1852422-1852120 [Vibrio parahaemolyticus]
MAEVIWTEPALSDLNDIAEYIALENVVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T49648 NZ_CP009765:c1852422-1852120 [Vibrio parahaemolyticus]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATATATCGCACTTGAAAATGTCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCGGAGTCAGGTCGCATTCCAC
CTGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGCGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT49648 WP_005448240.1 NZ_CP009765:c1852667-1852410 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT49648 NZ_CP009765:c1852667-1852410 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCATGACACTAAAGAACCCGT
GTTAATTACTGAACATGGTAAGCCATCTGCGTATCTCGTTGATGTTGATGACTATGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCAAGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGGTAAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References