Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3457019..3457691 Replicon chromosome
Accession NZ_CP009759
Organism Yersinia pseudotuberculosis strain EP2/+

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag BZ20_RS15845 Protein ID WP_002215144.1
Coordinates 3457266..3457691 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag BZ20_RS15840 Protein ID WP_002209939.1
Coordinates 3457019..3457285 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ20_RS15820 3452894..3453997 + 1104 WP_011192960.1 hypothetical protein -
BZ20_RS15825 3454198..3454899 + 702 WP_011192959.1 hemolysin III family protein -
BZ20_RS15830 3455140..3455637 + 498 WP_002209941.1 DUF2165 family protein -
BZ20_RS15835 3455710..3456702 - 993 WP_011192958.1 tRNA-modifying protein YgfZ -
BZ20_RS15840 3457019..3457285 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
BZ20_RS15845 3457266..3457691 + 426 WP_002215144.1 protein YgfX Toxin
BZ20_RS15850 3457691..3458389 + 699 WP_002209937.1 two-component system response regulator CreB -
BZ20_RS15855 3458400..3459818 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
BZ20_RS15860 3459918..3461375 + 1458 WP_032466588.1 cell envelope integrity protein CreD -
BZ20_RS15865 3461460..3461978 - 519 WP_011192956.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T49640 WP_002215144.1 NZ_CP009759:3457266-3457691 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T49640 NZ_CP009759:3457266-3457691 [Yersinia pseudotuberculosis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT49640 WP_002209939.1 NZ_CP009759:3457019-3457285 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT49640 NZ_CP009759:3457019-3457285 [Yersinia pseudotuberculosis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References