Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 3648532..3649288 | Replicon | chromosome |
| Accession | NZ_CP009757 | ||
| Organism | Yersinia pseudotuberculosis strain MD67 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A3G5KDU1 |
| Locus tag | BZ21_RS16440 | Protein ID | WP_032467110.1 |
| Coordinates | 3648532..3648900 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | Q664A5 |
| Locus tag | BZ21_RS16445 | Protein ID | WP_011193303.1 |
| Coordinates | 3648953..3649288 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BZ21_RS16410 | 3643600..3644607 | + | 1008 | WP_011193296.1 | iron chelate uptake ABC transporter family permease subunit | - |
| BZ21_RS16415 | 3644604..3645362 | + | 759 | WP_011193297.1 | ABC transporter ATP-binding protein | - |
| BZ21_RS16420 | 3645359..3645859 | - | 501 | WP_002214364.1 | virulence RhuM family protein | - |
| BZ21_RS16425 | 3645801..3646127 | - | 327 | WP_011193298.1 | hypothetical protein | - |
| BZ21_RS16430 | 3646150..3646557 | - | 408 | WP_011193299.1 | hypothetical protein | - |
| BZ21_RS22285 | 3646792..3647064 | - | 273 | WP_011193300.1 | Arm DNA-binding domain-containing protein | - |
| BZ21_RS16435 | 3647451..3648305 | - | 855 | WP_032467109.1 | DUF4942 domain-containing protein | - |
| BZ21_RS16440 | 3648532..3648900 | - | 369 | WP_032467110.1 | TA system toxin CbtA family protein | Toxin |
| BZ21_RS16445 | 3648953..3649288 | - | 336 | WP_011193303.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BZ21_RS16450 | 3649300..3649779 | - | 480 | WP_011193304.1 | hypothetical protein | - |
| BZ21_RS16455 | 3649962..3650582 | - | 621 | WP_011193305.1 | hypothetical protein | - |
| BZ21_RS16460 | 3650610..3651164 | - | 555 | WP_011193306.1 | hypothetical protein | - |
| BZ21_RS16465 | 3651412..3652056 | - | 645 | WP_080871705.1 | hypothetical protein | - |
| BZ21_RS16470 | 3652110..3652403 | - | 294 | Protein_3152 | ATP-binding protein | - |
| BZ21_RS16475 | 3653068..3653304 | + | 237 | Protein_3153 | inovirus Gp2 family protein | - |
| BZ21_RS16480 | 3653370..3654149 | - | 780 | WP_001297096.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3638043..3663168 | 25125 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13723.81 Da Isoelectric Point: 6.4530
>T49626 WP_032467110.1 NZ_CP009757:c3648900-3648532 [Yersinia pseudotuberculosis]
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
Download Length: 369 bp
>T49626 NZ_CP009757:c3648900-3648532 [Yersinia pseudotuberculosis]
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12452.06 Da Isoelectric Point: 6.0555
>AT49626 WP_011193303.1 NZ_CP009757:c3649288-3648953 [Yersinia pseudotuberculosis]
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
Download Length: 336 bp
>AT49626 NZ_CP009757:c3649288-3648953 [Yersinia pseudotuberculosis]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G5KDU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q664A5 |