Detailed information of TA system TA049624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1704385..1705351
• Replicon: chromosome
• Accession: NZ_CP009757
• Organism: Yersinia pseudotuberculosis strain MD67

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: BZ21_RS07875
• Protein ID: WP_011192520.1
• Coordinates: 1704893..1705351 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BZ21_RS07870
• Protein ID: WP_002210982.1
• Coordinates: 1704385..1704831 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ21_RS07850	1699912..1700619	+	708	WP_038823925.1	murein tripeptide amidase MpaA	-
BZ21_RS07855	1700661..1701641	-	981	WP_012413751.1	L-Ala-D/L-Glu epimerase	-
BZ21_RS07860	1701804..1702307	+	504	WP_002210984.1	thiol peroxidase	-
BZ21_RS07865	1702471..1704048	-	1578	WP_011192519.1	transcriptional regulator TyrR	-
BZ21_RS07870	1704385..1704831	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BZ21_RS07875	1704893..1705351	+	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
BZ21_RS07880	1705361..1706422	-	1062	WP_012413752.1	YcjF family protein	-
BZ21_RS07885	1706419..1707816	-	1398	WP_012105043.1	YcjX family protein	-
BZ21_RS07890	1707797..1708039	-	243	WP_002216375.1	phage shock protein PspD	-
BZ21_RS07895	1708124..1708483	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
BZ21_RS07900	1708483..1708710	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BZ21_RS07905	1708872..1709537	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T49624 WP_011192520.1 NZ_CP009757:1704893-1705351 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49624 NZ_CP009757:1704893-1705351 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49624 WP_002210982.1 NZ_CP009757:1704385-1704831 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49624 NZ_CP009757:1704385-1704831 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1