Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 247024..247644 Replicon chromosome
Accession NZ_CP009757
Organism Yersinia pseudotuberculosis strain MD67

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BZ21_RS01165 Protein ID WP_002208622.1
Coordinates 247024..247227 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag BZ21_RS01170 Protein ID WP_002218472.1
Coordinates 247276..247644 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ21_RS01140 242026..242364 + 339 WP_002208627.1 P-II family nitrogen regulator -
BZ21_RS01145 242404..243693 + 1290 WP_002228344.1 ammonium transporter AmtB -
BZ21_RS01150 243955..244815 - 861 WP_002208625.1 acyl-CoA thioesterase II -
BZ21_RS01155 245072..245593 + 522 WP_011191872.1 YbaY family lipoprotein -
BZ21_RS01160 245729..246118 - 390 WP_002208623.1 MGMT family protein -
BZ21_RS01165 247024..247227 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
BZ21_RS01170 247276..247644 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
BZ21_RS01175 247803..248156 - 354 WP_002208619.1 hypothetical protein -
BZ21_RS01180 249021..249164 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
BZ21_RS01185 249180..249440 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49614 WP_002208622.1 NZ_CP009757:c247227-247024 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49614 NZ_CP009757:c247227-247024 [Yersinia pseudotuberculosis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT49614 WP_002218472.1 NZ_CP009757:c247644-247276 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT49614 NZ_CP009757:c247644-247276 [Yersinia pseudotuberculosis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References