Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3933868..3934528 Replicon chromosome
Accession NZ_CP009756
Organism Enterobacter cloacae strain GGT036

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag EC036_RS18505 Protein ID WP_023620447.1
Coordinates 3933868..3934281 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag EC036_RS18510 Protein ID WP_013098615.1
Coordinates 3934262..3934528 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC036_RS18485 3929861..3931594 - 1734 WP_038420532.1 single-stranded-DNA-specific exonuclease RecJ -
EC036_RS18490 3931600..3932313 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EC036_RS18495 3932342..3933238 - 897 WP_038420533.1 site-specific tyrosine recombinase XerD -
EC036_RS18500 3933340..3933861 + 522 WP_013098613.1 flavodoxin FldB -
EC036_RS18505 3933868..3934281 - 414 WP_023620447.1 protein YgfX Toxin
EC036_RS18510 3934262..3934528 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
EC036_RS18515 3934823..3935803 + 981 WP_023620448.1 tRNA-modifying protein YgfZ -
EC036_RS18520 3935913..3936572 - 660 WP_003863433.1 hemolysin III family protein -
EC036_RS18530 3936838..3937569 + 732 WP_038420535.1 MurR/RpiR family transcriptional regulator -
EC036_RS18535 3937686..3939119 + 1434 WP_029883156.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T49612 WP_023620447.1 NZ_CP009756:c3934281-3933868 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T49612 NZ_CP009756:c3934281-3933868 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGTTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATCAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT49612 WP_013098615.1 NZ_CP009756:c3934528-3934262 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT49612 NZ_CP009756:c3934528-3934262 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References