Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 985102..985855 Replicon chromosome
Accession NZ_CP009756
Organism Enterobacter cloacae strain GGT036

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483K7K1
Locus tag EC036_RS23120 Protein ID WP_071843260.1
Coordinates 985487..985855 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8B4G4X8
Locus tag EC036_RS04615 Protein ID WP_032410127.1
Coordinates 985102..985452 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC036_RS04585 980278..981429 - 1152 WP_154231910.1 hypothetical protein -
EC036_RS04590 981527..982420 + 894 WP_038418748.1 50S ribosome-binding GTPase -
EC036_RS04595 982706..983383 + 678 WP_038418749.1 hypothetical protein -
EC036_RS04600 983479..984300 + 822 WP_038418750.1 DUF945 domain-containing protein -
EC036_RS04605 984371..984844 + 474 WP_038418751.1 DNA repair protein RadC -
EC036_RS04610 984860..985081 + 222 WP_038418752.1 DUF987 domain-containing protein -
EC036_RS04615 985102..985452 + 351 WP_032410127.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC036_RS23120 985487..985855 + 369 WP_071843260.1 TA system toxin CbtA family protein Toxin
EC036_RS04620 985942..986121 + 180 WP_172645244.1 hypothetical protein -
EC036_RS04625 986591..987376 + 786 WP_023620944.1 hypothetical protein -
EC036_RS04630 989146..989460 + 315 WP_038418754.1 hypothetical protein -
EC036_RS04635 989623..989943 + 321 WP_038418755.1 hypothetical protein -
EC036_RS04640 989940..990734 - 795 WP_038418756.1 DUF4225 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 966093..990734 24641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13763.93 Da        Isoelectric Point: 8.2789

>T49599 WP_071843260.1 NZ_CP009756:985487-985855 [Enterobacter cloacae]
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLVEKYELIRIDRRGF
SSQGPVPYLTVTDILHARRACGLTNSCPYREVSNIVLGRSRQ

Download         Length: 369 bp

>T49599 NZ_CP009756:985487-985855 [Enterobacter cloacae]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGACATGCTTATCACCCGTGGTTGTCTGGCAAATGCTGCTTGC
TCGACTACTTGAGCAGCACTATGGCCTGACCTTAAATGACACGCCGTTCAGCGATGAGGCTGTTATTAAAAGACATATCG
AAGCTGGTATCACGCTTGTCGATGCCGTTAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACCGCAGAGGATTT
AGCTCACAGGGACCAGTGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGTGGATTAACGAACAGTTG
TCCTTATCGGGAAGTAAGTAATATTGTTCTTGGCCGATCGCGGCAGTGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13014.93 Da        Isoelectric Point: 7.1865

>AT49599 WP_032410127.1 NZ_CP009756:985102-985452 [Enterobacter cloacae]
MSSKTLTVNDDTAEPWWGLNRNVIPCFGARLVQEGNRLYYLSDRASIIGLFNKADLLRLDQAFPVLLKQAELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGHVYISIYPTQR

Download         Length: 351 bp

>AT49599 NZ_CP009756:985102-985452 [Enterobacter cloacae]
ATGTCGAGTAAGACACTCACAGTGAATGATGATACCGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTT
TGGTGCGCGTCTGGTCCAGGAAGGTAACCGTCTATATTACCTGTCTGACCGCGCCAGCATAATAGGCCTATTCAATAAAG
CGGATTTGCTCCGTCTTGACCAGGCATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCGGCGAACTGAAT
CCCCGACACCAGCATTGCGTCACCCTCTATGCAAAGGGGCTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGTCACGT
CTATATCTCCATTTATCCTACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483K7K1

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4G4X8

References