Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 181472..182076 Replicon chromosome
Accession NZ_CP009756
Organism Enterobacter cloacae strain GGT036

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag EC036_RS22995 Protein ID WP_071843252.1
Coordinates 181472..181657 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5E1AFC9
Locus tag EC036_RS00880 Protein ID WP_023621194.1
Coordinates 181672..182076 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC036_RS00865 177903..179441 + 1539 WP_020686520.1 aldehyde dehydrogenase -
EC036_RS00870 179438..180403 - 966 WP_061771396.1 LysR family transcriptional regulator -
EC036_RS00875 180521..181261 + 741 WP_013094942.1 MipA/OmpV family protein -
EC036_RS22995 181472..181657 + 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
EC036_RS00880 181672..182076 + 405 WP_023621194.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EC036_RS00885 182130..184085 - 1956 WP_038418387.1 glycoside hydrolase family 127 protein -
EC036_RS00890 184096..185496 - 1401 WP_020686524.1 MFS transporter -
EC036_RS00895 185721..186539 + 819 WP_020686525.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T49595 WP_071843252.1 NZ_CP009756:181472-181657 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T49595 NZ_CP009756:181472-181657 [Enterobacter cloacae]
GTGAAAAGTGCGGATGTCATTACTGTTCTGGTCAGGCATGGCTGGAAATGTGTAAGAACGAAAGGAAGCCATCATCAGTT
TCGCCACCCAGTACATGCGGGGTTGGTGACCGTTCCACATCCCAAAAAGGACATAAAACCCGGCACCCTCGCGCAAATCT
GGCGGCAGGCGGGAATCAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14888.72 Da        Isoelectric Point: 4.3036

>AT49595 WP_023621194.1 NZ_CP009756:181672-182076 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT49595 NZ_CP009756:181672-182076 [Enterobacter cloacae]
ATGTTTTATCCGGCTTACATTCATTCTGATCCCGACGGTAGCGCCAGCGGTTTTTTTCCTGACGTTCCTGGTTGTTTTTT
TGCCGGCAATTCTCTGGATGATGCTTTTCAGGATGCACGTGATGCACTGACAGCTCACTTCGAAGCGCTATTTGAAATGG
ATGAAGAGTTACCTCTCCCTGGCAATGTTGAAGCACATCTTGAAGCCACACCGGGTGATTTTATCGGCGGACAATGGTTG
CTTGTAGATATCAATATGAAGCAATTCGACGGTAAGGCCGAGCGTATCAATATCACCCTGCCTCGTCGATTGCTGGTGAA
AATTGATTCTTTTGTGAGTGAGCATCCGCAGTTTAGTAACCGAAGCGCTTTTCTGGCTGAGGCAGCGCGTCGCGTGCTGC
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFC9

References