Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 544847..545502 Replicon chromosome
Accession NZ_CP009737
Organism Burkholderia mallei strain Turkey7

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag NW96_RS02870 Protein ID WP_004199884.1
Coordinates 545206..545502 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag NW96_RS02865 Protein ID WP_004202809.1
Coordinates 544847..545203 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW96_RS02835 540979..541737 + 759 WP_004199892.1 cytochrome c1 -
NW96_RS02840 541830..542441 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
NW96_RS02845 542511..543032 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
NW96_RS02855 543254..543751 + 498 WP_004199888.1 terminase -
NW96_RS02860 543748..544803 + 1056 WP_004199886.1 phage portal protein -
NW96_RS02865 544847..545203 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
NW96_RS02870 545206..545502 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW96_RS02875 546310..547430 + 1121 WP_038802950.1 IS3 family transposase -
NW96_RS02880 547478..548029 + 552 Protein_495 flagellar type III secretion system pore protein FliP -
NW96_RS02885 548055..548327 + 273 WP_004199882.1 flagellar biosynthesis protein FliQ -
NW96_RS02890 548446..549228 + 783 WP_004201278.1 flagellar biosynthetic protein FliR -
NW96_RS02895 549548..549976 - 429 WP_004199881.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliP / fliQ / fliR 543437..549976 6539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T49564 WP_004199884.1 NZ_CP009737:c545502-545206 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49564 NZ_CP009737:c545502-545206 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49564 WP_004202809.1 NZ_CP009737:c545203-544847 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49564 NZ_CP009737:c545203-544847 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References