Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 544845..545500 Replicon chromosome
Accession NZ_CP009725
Organism Burkholderia mallei strain Turkey1

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag NM78_RS02865 Protein ID WP_004199884.1
Coordinates 545204..545500 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag NM78_RS02860 Protein ID WP_004202809.1
Coordinates 544845..545201 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM78_RS02830 540977..541735 + 759 WP_004199892.1 cytochrome c1 -
NM78_RS02835 541828..542439 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
NM78_RS02840 542509..543030 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
NM78_RS02850 543252..543749 + 498 WP_004199888.1 terminase -
NM78_RS02855 543746..544801 + 1056 WP_004199886.1 phage portal protein -
NM78_RS02860 544845..545201 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
NM78_RS02865 545204..545500 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NM78_RS02870 546308..547428 + 1121 WP_038802950.1 IS3 family transposase -
NM78_RS02875 547476..548027 + 552 Protein_494 flagellar type III secretion system pore protein FliP -
NM78_RS02880 548053..548325 + 273 WP_004199882.1 flagellar biosynthesis protein FliQ -
NM78_RS02885 548444..549226 + 783 WP_004201278.1 flagellar biosynthetic protein FliR -
NM78_RS02890 549546..549974 - 429 WP_004199881.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliP / fliQ / fliR 543435..549974 6539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T49546 WP_004199884.1 NZ_CP009725:c545500-545204 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49546 NZ_CP009725:c545500-545204 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49546 WP_004202809.1 NZ_CP009725:c545201-544845 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49546 NZ_CP009725:c545201-544845 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References