Detailed information of TA system TA049534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1288788..1289754
• Replicon: chromosome
• Accession: NZ_CP009723
• Organism: Yersinia pestis strain Shasta

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: BZ15_RS07090
• Protein ID: WP_002210981.1
• Coordinates: 1288788..1289246 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BZ15_RS07095
• Protein ID: WP_002210982.1
• Coordinates: 1289308..1289754 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ15_RS07060	1284602..1285267	+	666	WP_002210975.1	phage shock protein PspA	-
BZ15_RS07065	1285429..1285656	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BZ15_RS07070	1285656..1286015	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
BZ15_RS07075	1286100..1286342	+	243	WP_002216375.1	phage shock protein PspD	-
BZ15_RS07080	1286323..1287720	+	1398	WP_002210979.1	YcjX family protein	-
BZ15_RS07085	1287717..1288778	+	1062	WP_002210980.1	YcjF family protein	-
BZ15_RS07090	1288788..1289246	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
BZ15_RS07095	1289308..1289754	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BZ15_RS07100	1290089..1291666	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
BZ15_RS07105	1291813..1292270	-	458	Protein_1144	IS200/IS605 family transposase	-
BZ15_RS07110	1292523..1293026	-	504	WP_002210984.1	thiol peroxidase	-
BZ15_RS07115	1293189..1294163	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1291813..1292058	245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T49534 WP_002210981.1 NZ_CP009723:c1289246-1288788 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49534 NZ_CP009723:c1289246-1288788 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49534 WP_002210982.1 NZ_CP009723:c1289754-1289308 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49534 NZ_CP009723:c1289754-1289308 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1