Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2452051..2453026 Replicon chromosome
Accession NZ_CP009720
Organism Bacillus thuringiensis strain HD682

Toxin (Protein)


Gene name spoIISA Uniprot ID C3G356
Locus tag BF36_RS13415 Protein ID WP_003294136.1
Coordinates 2452289..2453026 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BF36_RS13410 Protein ID WP_000588712.1
Coordinates 2452051..2452176 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF36_RS13380 2447806..2448276 + 471 WP_000670597.1 DUF5065 family protein -
BF36_RS13385 2448840..2450309 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BF36_RS29720 2450453..2450629 - 177 WP_000808045.1 hypothetical protein -
BF36_RS13395 2450968..2451204 + 237 WP_001021688.1 hypothetical protein -
BF36_RS13400 2451481..2451762 + 282 WP_001041555.1 hypothetical protein -
BF36_RS29725 2451799..2451975 - 177 WP_042511279.1 hypothetical protein -
BF36_RS13410 2452051..2452176 - 126 WP_000588712.1 hypothetical protein Antitoxin
BF36_RS13415 2452289..2453026 - 738 WP_003294136.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF36_RS13420 2453215..2453952 - 738 WP_000594156.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF36_RS13425 2454120..2454602 - 483 WP_000191912.1 MarR family winged helix-turn-helix transcriptional regulator -
BF36_RS13430 2454709..2456394 + 1686 WP_052495366.1 alpha-keto acid decarboxylase family protein -
BF36_RS13435 2456516..2456826 - 311 Protein_2531 hypothetical protein -
BF36_RS13440 2457087..2457494 - 408 WP_000072501.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28359.05 Da        Isoelectric Point: 8.2672

>T49530 WP_003294136.1 NZ_CP009720:c2453026-2452289 [Bacillus thuringiensis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVVDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T49530 NZ_CP009720:c2453026-2452289 [Bacillus thuringiensis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTGTTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT49530 WP_000588712.1 NZ_CP009720:c2452176-2452051 [Bacillus thuringiensis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT49530 NZ_CP009720:c2452176-2452051 [Bacillus thuringiensis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H9IF90

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References