Detailed information of TA system TA049529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3237153..3238119
• Replicon: chromosome
• Accession: NZ_CP009715
• Organism: Yersinia pestis Pestoides F

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: BZ18_RS16160
• Protein ID: WP_002210981.1
• Coordinates: 3237661..3238119 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BZ18_RS16155
• Protein ID: WP_002210982.1
• Coordinates: 3237153..3237599 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ18_RS16135	3232685..3233707	+	1023	WP_011901829.1	IS21-like element IS100 family transposase	-
BZ18_RS16140	3233707..3234486	+	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
BZ18_RS16145	3234635..3235093	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
BZ18_RS16150	3235240..3236817	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
BZ18_RS16155	3237153..3237599	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BZ18_RS16160	3237661..3238119	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
BZ18_RS16165	3238129..3239190	-	1062	WP_002210980.1	YcjF family protein	-
BZ18_RS16170	3239187..3240584	-	1398	WP_011906190.1	YcjX family protein	-
BZ18_RS16175	3240565..3240807	-	243	WP_002216375.1	phage shock protein PspD	-
BZ18_RS16180	3240892..3241251	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
BZ18_RS16185	3241251..3241478	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BZ18_RS16190	3241640..3242305	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T49529 WP_002210981.1 NZ_CP009715:3237661-3238119 [Yersinia pestis Pestoides F]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49529 NZ_CP009715:3237661-3238119 [Yersinia pestis Pestoides F]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49529 WP_002210982.1 NZ_CP009715:3237153-3237599 [Yersinia pestis Pestoides F]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49529 NZ_CP009715:3237153-3237599 [Yersinia pestis Pestoides F]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1