Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 3021318..3022074 | Replicon | chromosome |
| Accession | NZ_CP009712 | ||
| Organism | Yersinia pseudotuberculosis IP 32953 strain IP32953 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A3G5KDU1 |
| Locus tag | BZ17_RS14375 | Protein ID | WP_032467110.1 |
| Coordinates | 3021706..3022074 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | Q664A5 |
| Locus tag | BZ17_RS14370 | Protein ID | WP_011193303.1 |
| Coordinates | 3021318..3021653 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BZ17_RS14340 | 3016936..3017556 | - | 621 | WP_011193309.1 | inovirus Gp2 family protein | - |
| BZ17_RS14345 | 3018221..3018514 | + | 294 | Protein_2613 | ATP-binding protein | - |
| BZ17_RS14350 | 3018568..3019194 | + | 627 | WP_024063555.1 | hypothetical protein | - |
| BZ17_RS14355 | 3019442..3019996 | + | 555 | WP_011193306.1 | hypothetical protein | - |
| BZ17_RS14360 | 3020024..3020644 | + | 621 | WP_011193305.1 | hypothetical protein | - |
| BZ17_RS14365 | 3020827..3021306 | + | 480 | WP_011193304.1 | hypothetical protein | - |
| BZ17_RS14370 | 3021318..3021653 | + | 336 | WP_011193303.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BZ17_RS14375 | 3021706..3022074 | + | 369 | WP_032467110.1 | TA system toxin CbtA family protein | Toxin |
| BZ17_RS14380 | 3022301..3023155 | + | 855 | WP_032467109.1 | DUF4942 domain-containing protein | - |
| BZ17_RS22915 | 3023518..3023790 | + | 273 | WP_011193300.1 | Arm DNA-binding domain-containing protein | - |
| BZ17_RS14385 | 3024025..3024432 | + | 408 | WP_011193299.1 | hypothetical protein | - |
| BZ17_RS14390 | 3024455..3024781 | + | 327 | WP_011193298.1 | hypothetical protein | - |
| BZ17_RS14395 | 3024723..3025223 | + | 501 | WP_002214364.1 | virulence RhuM family protein | - |
| BZ17_RS14400 | 3025220..3025978 | - | 759 | WP_011193297.1 | ABC transporter ATP-binding protein | - |
| BZ17_RS14405 | 3025975..3026982 | - | 1008 | WP_011193296.1 | iron chelate uptake ABC transporter family permease subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13723.81 Da Isoelectric Point: 6.4530
>T49513 WP_032467110.1 NZ_CP009712:3021706-3022074 [Yersinia pseudotuberculosis IP 32953]
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
Download Length: 369 bp
>T49513 NZ_CP009712:3021706-3022074 [Yersinia pseudotuberculosis IP 32953]
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12452.06 Da Isoelectric Point: 6.0555
>AT49513 WP_011193303.1 NZ_CP009712:3021318-3021653 [Yersinia pseudotuberculosis IP 32953]
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
Download Length: 336 bp
>AT49513 NZ_CP009712:3021318-3021653 [Yersinia pseudotuberculosis IP 32953]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G5KDU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q664A5 |