Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1719644..1720264 Replicon chromosome
Accession NZ_CP009712
Organism Yersinia pseudotuberculosis IP 32953 strain IP32953

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BZ17_RS08480 Protein ID WP_002208622.1
Coordinates 1720061..1720264 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag BZ17_RS08475 Protein ID WP_002218472.1
Coordinates 1719644..1720012 (+) Length 123 a.a.

Genomic Context

BZ17_RS08460BZ17_RS08465BZ17_RS08470BZ17_RS08475BZ17_RS08480BZ17_RS08485BZ17_RS08495BZ17_RS08490BZ17_RS08500BZ17_RS08505
Location: 1717849..1718109 (261 bp)
Type: Others
Protein ID: WP_002208617.1
Location: 1718125..1718268 (144 bp)
Type: Others
Protein ID: WP_002208618.1
Location: 1719132..1719485 (354 bp)
Type: Others
Protein ID: WP_002208619.1
Location: 1719644..1720012 (369 bp)
Type: Antitoxin
Protein ID: WP_002218472.1
Location: 1720061..1720264 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 1721170..1721559 (390 bp)
Type: Others
Protein ID: WP_002208623.1
Location: 1722473..1723333 (861 bp)
Type: Others
Protein ID: WP_002208625.1
Location: 1721695..1722216 (522 bp)
Type: Others
Protein ID: WP_011191872.1
Location: 1723595..1724884 (1290 bp)
Type: Others
Protein ID: WP_002228344.1
Location: 1724924..1725262 (339 bp)
Type: Others
Protein ID: WP_002208627.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BZ17_RS084601717849..1718109+261WP_002208617.1type B 50S ribosomal protein L31-
BZ17_RS084651718125..1718268+144WP_002208618.1type B 50S ribosomal protein L36-
BZ17_RS084701719132..1719485+354WP_002208619.1hypothetical protein-
BZ17_RS084751719644..1720012+369WP_002218472.1Hha toxicity modulator TomBAntitoxin
BZ17_RS084801720061..1720264+204WP_002208622.1expression modulating protein YmoAToxin
BZ17_RS084851721170..1721559+390WP_002208623.1MGMT family protein-
BZ17_RS084901721695..1722216-522WP_011191872.1YbaY family lipoprotein-
BZ17_RS084951722473..1723333+861WP_002208625.1acyl-CoA thioesterase II-
BZ17_RS085001723595..1724884-1290WP_002228344.1ammonium transporter AmtB-
BZ17_RS085051724924..1725262-339WP_002208627.1P-II family nitrogen regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49512 WP_002208622.1 NZ_CP009712:1720061-1720264 [Yersinia pseudotuberculosis IP 32953]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49512 NZ_CP009712:1720061-1720264 [Yersinia pseudotuberculosis IP 32953]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT49512 WP_002218472.1 NZ_CP009712:1719644-1720012 [Yersinia pseudotuberculosis IP 32953]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT49512 NZ_CP009712:1719644-1720012 [Yersinia pseudotuberculosis IP 32953]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2K5S

Antitoxin

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Source
ID
Structure
AlphaFold DBQ66DR4

References