Detailed information of TA system TA049503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 220798..221781
• Replicon: chromosome
• Accession: NZ_CP009712
• Organism: Yersinia pseudotuberculosis IP 32953 strain IP32953

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: BZ17_RS01560
• Protein ID: WP_011192520.1
• Coordinates: 220798..221256 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BZ17_RS01565
• Protein ID: WP_002210982.1
• Coordinates: 221335..221781 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ17_RS01530	216612..217277	+	666	WP_011192521.1	phage shock protein PspA	-
BZ17_RS01535	217439..217666	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BZ17_RS01540	217666..218025	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
BZ17_RS01545	218110..218352	+	243	WP_002216375.1	phage shock protein PspD	-
BZ17_RS01550	218333..219730	+	1398	WP_002210979.1	YcjX family protein	-
BZ17_RS01555	219727..220788	+	1062	WP_002210980.1	YcjF family protein	-
BZ17_RS01560	220798..221256	-	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
BZ17_RS01565	221335..221781	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BZ17_RS01570	222118..223695	+	1578	WP_011192519.1	transcriptional regulator TyrR	-
BZ17_RS01575	223859..224362	-	504	WP_002210984.1	thiol peroxidase	-
BZ17_RS01580	224525..225499	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
BZ17_RS01585	225541..226248	-	708	WP_038823925.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T49503 WP_011192520.1 NZ_CP009712:c221256-220798 [Yersinia pseudotuberculosis IP 32953]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49503 NZ_CP009712:c221256-220798 [Yersinia pseudotuberculosis IP 32953]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49503 WP_002210982.1 NZ_CP009712:c221781-221335 [Yersinia pseudotuberculosis IP 32953]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49503 NZ_CP009712:c221781-221335 [Yersinia pseudotuberculosis IP 32953]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCTAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1