Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 15332..15866 Replicon plasmid pYAC_1
Accession NZ_CP009711
Organism Yersinia pseudotuberculosis IP 32953 strain IP32953

Toxin (Protein)


Gene name parE Uniprot ID Q663N8
Locus tag BZ17_RS00250 Protein ID WP_002213360.1
Coordinates 15567..15866 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BZ17_RS00245 Protein ID WP_012414146.1
Coordinates 15332..15574 (+) Length 81 a.a.

Genomic Context

BZ17_RS00230BZ17_RS00235BZ17_RS24170BZ17_RS23355BZ17_RS00245BZ17_RS00250BZ17_RS00260BZ17_RS00275BZ17_RS00280BZ17_RS00285BZ17_RS24285BZ17_RS00255BZ17_RS00265
Location: 11897..13063 (1167 bp)
Type: Others
Protein ID: WP_002220902.1
Location: 13060..14025 (966 bp)
Type: Others
Protein ID: WP_011191369.1
Location: 14185..14466 (282 bp)
Type: Others
Protein ID: WP_157868821.1
Location: 14874..15166 (293 bp)
Type: Others
Protein ID: Protein_20
Location: 15332..15574 (243 bp)
Type: Antitoxin
Protein ID: WP_012414146.1
Location: 15567..15866 (300 bp)
Type: Toxin
Protein ID: WP_002213360.1
Location: 16859..17251 (393 bp)
Type: Others
Protein ID: WP_002213403.1
Location: 18061..19233 (1173 bp)
Type: Others
Protein ID: WP_011191364.1
Location: 19233..19631 (399 bp)
Type: Others
Protein ID: Protein_27
Location: 20009..20434 (426 bp)
Type: Others
Protein ID: WP_002213267.1
Location: 14616..14789 (174 bp)
Type: Others
Protein ID: WP_002213357.1
Location: 16006..16665 (660 bp)
Type: Others
Protein ID: WP_002229754.1
Location: 17314..17958 (645 bp)
Type: Others
Protein ID: Protein_25
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BZ17_RS0023011897..13063+1167WP_002220902.1plasmid-partitioning protein SopA-
BZ17_RS0023513060..14025+966WP_011191369.1ParB/RepB/Spo0J family plasmid partition protein-
BZ17_RS2417014185..14466+282WP_157868821.1hypothetical protein-
BZ17_RS2428514616..14789-174WP_002213357.1hypothetical protein-
BZ17_RS2335514874..15166+293Protein_20IS6 family transposase-
BZ17_RS0024515332..15574+243WP_012414146.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
BZ17_RS0025015567..15866+300WP_002213360.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BZ17_RS0025516006..16665-660WP_002229754.1type III secretion system effector GTPase activator YopE-
BZ17_RS0026016859..17251+393WP_002213403.1type III secretion system chaperone SycE/YerA-
BZ17_RS0026517314..17958-645Protein_25IS3 family transposase-
BZ17_RS0027518061..19233+1173WP_011191364.1IS21 family transposase-
BZ17_RS0028019233..19631+399Protein_27ATP-binding protein-
BZ17_RS0028520009..20434+426WP_002213267.1type III secretion system chaperone SycH-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-yopD / sycT / yopT / yopK/yopQ / yopE / sycE/yerA / sycH / yadA / yopO/ypkA / yopJ/yopP / yopH / lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscP / yscO / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB1..6852568525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11632.19 Da        Isoelectric Point: 5.5114

>T49502 WP_002213360.1 NZ_CP009711:15567-15866 [Yersinia pseudotuberculosis IP 32953]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Download         Length: 300 bp

>T49502 NZ_CP009711:15567-15866 [Yersinia pseudotuberculosis IP 32953]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8807.12 Da        Isoelectric Point: 6.8783

>AT49502 WP_012414146.1 NZ_CP009711:15332-15574 [Yersinia pseudotuberculosis IP 32953]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKGTSV

Download         Length: 243 bp

>AT49502 NZ_CP009711:15332-15574 [Yersinia pseudotuberculosis IP 32953]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGGTACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ663N8

Antitoxin

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Source
ID
Structure
No matching records found

References