Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1502592..1503247 Replicon chromosome
Accession NZ_CP009707
Organism Burkholderia mallei strain 2002734306

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BO06_RS06900 Protein ID WP_004199884.1
Coordinates 1502951..1503247 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BO06_RS06895 Protein ID WP_004202809.1
Coordinates 1502592..1502948 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BO06_RS06865 1498724..1499482 + 759 WP_004199892.1 cytochrome c1 -
BO06_RS06870 1499575..1500186 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BO06_RS06875 1500256..1500777 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BO06_RS06885 1500999..1501496 + 498 WP_004199888.1 terminase -
BO06_RS06890 1501493..1502548 + 1056 WP_004199886.1 phage portal protein -
BO06_RS06895 1502592..1502948 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BO06_RS06900 1502951..1503247 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BO06_RS06910 1504055..1505175 + 1121 WP_123809469.1 IS3 family transposase -
BO06_RS06915 1505314..1505796 + 483 WP_004204912.1 type VI secretion system baseplate subunit TssE -
BO06_RS06920 1505876..1507714 + 1839 WP_004202808.1 type VI secretion system baseplate subunit TssF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1501182..1524865 23683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T49498 WP_004199884.1 NZ_CP009707:c1503247-1502951 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49498 NZ_CP009707:c1503247-1502951 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49498 WP_004202809.1 NZ_CP009707:c1502948-1502592 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49498 NZ_CP009707:c1502948-1502592 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References