49486

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 2451922..2452716 Replicon chromosome
Accession NZ_CP009706
Organism Hafnia alvei FB1

Toxin (Protein)


Gene name ataT Uniprot ID A0A097R2E8
Locus tag AT03_RS11260 Protein ID WP_025801386.1
Coordinates 2452195..2452716 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A097R2F1
Locus tag AT03_RS11255 Protein ID WP_025801385.1
Coordinates 2451922..2452191 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT03_RS11240 2447518..2448549 - 1032 WP_025801382.1 Mal regulon transcriptional regulator MalI -
AT03_RS11245 2448800..2450395 + 1596 WP_025801383.1 maltose/glucose-specific PTS transporter subunit IIBC -
AT03_RS11250 2450479..2451654 + 1176 WP_025801384.1 pyridoxal phosphate-dependent aminotransferase -
AT03_RS11255 2451922..2452191 + 270 WP_025801385.1 DUF1778 domain-containing protein Antitoxin
AT03_RS11260 2452195..2452716 + 522 WP_025801386.1 GNAT family N-acetyltransferase Toxin
AT03_RS11265 2452914..2453912 + 999 WP_025801387.1 adenosine deaminase -
AT03_RS11270 2454650..2455645 - 996 WP_025801029.1 bile acid:sodium symporter -
AT03_RS11275 2455807..2456850 - 1044 WP_025801030.1 oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-152)

Antitoxin

Vibrio phage ICP1, Orf50

(3-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19396.20 Da        Isoelectric Point: 6.9676

>T49486 WP_025801386.1 NZ_CP009706:2452195-2452716 [Hafnia alvei FB1]
MPDLTIAIFSSEAEYDFSDFDCGEESLNVFLTDHLARQHNARILRGYLLITQTPKPKVVGYYTLSGSCFEKETLPSNTQK
RKVPYVNVPSITLGRLAIQKDLHGQEWGTALVTHAMQVVYRASLAVGVHGMFVDALNEKAKQFYLKLGFIALTGNNANSL
FYPTKSIEKLFED

Download         Length: 522 bp

>T49486 NZ_CP009706:2452195-2452716 [Hafnia alvei FB1]
ATGCCTGACTTAACCATTGCGATTTTTTCGAGTGAGGCTGAATACGATTTCTCCGACTTTGACTGCGGCGAAGAATCCCT
GAATGTATTCCTTACCGATCATTTGGCCCGCCAGCATAATGCGCGAATTTTACGTGGCTATTTACTCATAACCCAAACGC
CAAAACCCAAAGTCGTTGGTTATTACACGCTATCTGGTAGCTGCTTCGAAAAGGAAACGCTGCCGTCAAATACCCAGAAA
CGCAAAGTGCCTTATGTCAACGTACCCAGTATCACTTTAGGGCGTCTCGCCATTCAAAAAGATCTCCATGGACAAGAATG
GGGAACGGCGCTGGTAACTCACGCGATGCAAGTGGTCTATCGAGCATCGCTCGCCGTGGGCGTTCACGGTATGTTTGTCG
ATGCACTCAATGAGAAAGCAAAGCAGTTCTACCTGAAGCTTGGATTTATCGCTCTCACGGGCAATAACGCAAACTCGCTT
TTCTATCCAACCAAATCCATCGAAAAGCTGTTCGAGGATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10097.51 Da        Isoelectric Point: 5.8580

>AT49486 WP_025801385.1 NZ_CP009706:2451922-2452191 [Hafnia alvei FB1]
MSALKKQRIDLRLTDEDKNAIEEAAAMSNQTITQFMLTSASERAAEVIEQHRRLILSDESWNLVMDAISTPPAPNDRLKR
AAKRLQSME

Download         Length: 270 bp

>AT49486 NZ_CP009706:2451922-2452191 [Hafnia alvei FB1]
ATGTCTGCATTAAAAAAACAGCGTATCGATCTTCGATTAACTGACGAAGACAAAAACGCCATTGAAGAAGCTGCGGCGAT
GTCCAACCAAACTATCACGCAGTTTATGCTTACCAGCGCCTCTGAACGTGCAGCGGAAGTTATCGAGCAACACCGTCGCT
TGATCCTCAGCGATGAGTCATGGAATCTGGTAATGGATGCCATCAGCACCCCACCGGCACCGAACGATAGACTTAAACGC
GCAGCCAAACGTCTGCAAAGTATGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097R2E8

Antitoxin

Source ID Structure
AlphaFold DB A0A097R2F1

References