Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3433860..3434838 Replicon chromosome
Accession NZ_CP009692
Organism Bacillus mycoides strain ATCC 6462

Toxin (Protein)


Gene name spoIISA Uniprot ID J8I6P2
Locus tag BG05_RS19445 Protein ID WP_002017051.1
Coordinates 3434098..3434838 (-) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BG05_RS19440 Protein ID WP_000588712.1
Coordinates 3433860..3433985 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG05_RS19415 3429595..3430254 - 660 WP_003189261.1 CatB-related O-acetyltransferase -
BG05_RS31135 3430968..3431117 - 150 WP_002069316.1 hypothetical protein -
BG05_RS19425 3431477..3432946 - 1470 WP_003189257.1 aminoacyl-histidine dipeptidase -
BG05_RS19430 3433198..3433587 + 390 WP_033733970.1 YxeA family protein -
BG05_RS31140 3433608..3433784 - 177 WP_003189253.1 hypothetical protein -
BG05_RS19440 3433860..3433985 - 126 WP_000588712.1 hypothetical protein Antitoxin
BG05_RS19445 3434098..3434838 - 741 WP_002017051.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BG05_RS19450 3435177..3435914 - 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BG05_RS19455 3436068..3436544 - 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
BG05_RS19460 3436818..3437450 + 633 WP_002017047.1 glutamine amidotransferase -
BG05_RS19465 3437627..3438040 - 414 WP_002012925.1 VOC family protein -
BG05_RS19470 3438159..3438869 - 711 WP_002127421.1 class I SAM-dependent methyltransferase -
BG05_RS19475 3438975..3439736 - 762 WP_002127420.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28512.20 Da        Isoelectric Point: 8.3034

>T49460 WP_002017051.1 NZ_CP009692:c3434838-3434098 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T49460 NZ_CP009692:c3434838-3434098 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT49460 WP_000588712.1 NZ_CP009692:c3433985-3433860 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT49460 NZ_CP009692:c3433985-3433860 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J8I6P2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References