Detailed information of TA system TA049417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2337714..2338243
• Replicon: chromosome
• Accession: NZ_CP009681
• Organism: Staphylococcus aureus strain Gv69

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SAGV69_RS12205
• Protein ID: WP_000621175.1
• Coordinates: 2337714..2338076 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SAGV69_RS12210
• Protein ID: WP_000948331.1
• Coordinates: 2338073..2338243 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV69_RS12180	2334693..2335463	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
SAGV69_RS12185	2335438..2335917	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
SAGV69_RS12190	2335919..2336245	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SAGV69_RS12195	2336364..2337365	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
SAGV69_RS12205	2337714..2338076	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SAGV69_RS12210	2338073..2338243	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SAGV69_RS12215	2338328..2339476	-	1149	WP_001281145.1	alanine racemase	-
SAGV69_RS12220	2339542..2339901	-	360	WP_000581200.1	holo-ACP synthase	-
SAGV69_RS12225	2339905..2340396	-	492	WP_001205910.1	PH domain-containing protein	-
SAGV69_RS12230	2340383..2341966	-	1584	WP_001294626.1	PH domain-containing protein	-
SAGV69_RS12235	2341959..2342438	-	480	WP_001287088.1	hypothetical protein	-
SAGV69_RS12240	2342646..2343206	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T49417 WP_000621175.1 NZ_CP009681:c2338076-2337714 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T49417 NZ_CP009681:c2338076-2337714 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT49417 WP_000948331.1 NZ_CP009681:c2338243-2338073 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT49417 NZ_CP009681:c2338243-2338073 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1