49412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1688602..1689079 Replicon chromosome
Accession NZ_CP009681
Organism Staphylococcus aureus strain Gv69

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAGV69_RS08780 Protein ID WP_000052078.1
Coordinates 1688891..1689079 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAGV69_RS08775 Protein ID WP_001059690.1
Coordinates 1688602..1688862 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV69_RS08740 1683995..1684711 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
SAGV69_RS08745 1684859..1685281 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAGV69_RS08750 1685680..1686174 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAGV69_RS08755 1686329..1686946 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAGV69_RS08760 1687019..1687600 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
SAGV69_RS08765 1687825..1688061 + 237 WP_000368687.1 hypothetical protein -
SAGV69_RS08770 1688058..1688261 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAGV69_RS08775 1688602..1688862 + 261 WP_001059690.1 hypothetical protein Antitoxin
SAGV69_RS08780 1688891..1689079 + 189 WP_000052078.1 hypothetical protein Toxin
SAGV69_RS08785 1689309..1690481 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
SAGV69_RS08790 1690598..1691167 + 570 WP_001106654.1 hypothetical protein -
SAGV69_RS08795 1691255..1691539 + 285 WP_001004395.1 hypothetical protein -
SAGV69_RS08800 1691601..1691819 + 219 WP_000005886.1 hypothetical protein -
SAGV69_RS08805 1692315..1692515 - 201 WP_001059082.1 cold-shock protein -
SAGV69_RS08810 1692712..1693883 + 1172 Protein_1681 IS256-like element IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1664488..1697057 32569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T49412 WP_000052078.1 NZ_CP009681:1688891-1689079 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T49412 NZ_CP009681:1688891-1689079 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT49412 WP_001059690.1 NZ_CP009681:1688602-1688862 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT49412 NZ_CP009681:1688602-1688862 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References