Detailed information of TA system TA049408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 917274..918077
• Replicon: chromosome
• Accession: NZ_CP009681
• Organism: Staphylococcus aureus strain Gv69

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2I7Y5B3
• Locus tag: SAGV69_RS04775
• Protein ID: WP_000525004.1
• Coordinates: 917274..917735 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SAGV69_RS04780
• Protein ID: WP_001573842.1
• Coordinates: 917748..918077 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV69_RS17225	912284..914310	+	2027	Protein_895	hypothetical protein	-
SAGV69_RS04755	914353..915558	-	1206	WP_020444721.1	site-specific integrase	-
SAGV69_RS16970	915684..916299	+	616	Protein_897	ATPase	-
SAGV69_RS04765	916296..916442	-	147	WP_001013104.1	hypothetical protein	-
SAGV69_RS04770	916672..917256	-	585	WP_000825948.1	hypothetical protein	-
SAGV69_RS04775	917274..917735	-	462	WP_000525004.1	hypothetical protein	Toxin
SAGV69_RS04780	917748..918077	-	330	WP_001573842.1	helix-turn-helix domain-containing protein	Antitoxin
SAGV69_RS04785	918269..918514	+	246	WP_001573844.1	helix-turn-helix domain-containing protein	-
SAGV69_RS04790	918528..919304	+	777	WP_031886646.1	Rha family transcriptional regulator	-
SAGV69_RS04795	919333..919476	+	144	WP_000939498.1	hypothetical protein	-
SAGV69_RS04800	919466..919675	-	210	WP_000642492.1	hypothetical protein	-
SAGV69_RS04805	919731..919976	+	246	WP_001025401.1	DUF2829 domain-containing protein	-
SAGV69_RS04810	919945..920310	-	366	WP_001128433.1	hypothetical protein	-
SAGV69_RS04815	920365..920580	+	216	WP_001097552.1	hypothetical protein	-
SAGV69_RS04820	920605..920868	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAGV69_RS04825	920881..921042	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAGV69_RS04830	921121..921444	+	324	WP_000175001.1	hypothetical protein	-
SAGV69_RS04835	921459..921821	+	363	WP_000985984.1	hypothetical protein	-
SAGV69_RS04840	921818..922984	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18074.46 Da
• Isoelectric Point: 4.6915

>T49408 WP_000525004.1 NZ_CP009681:c917735-917274 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T49408 NZ_CP009681:c917735-917274 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12730.33 Da
• Isoelectric Point: 6.4836

>AT49408 WP_001573842.1 NZ_CP009681:c918077-917748 [Staphylococcus aureus]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 330 bp

>AT49408 NZ_CP009681:c918077-917748 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAA
ACGTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A2I7Y5B3