Detailed information of TA system TA049399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4645453..4646087
• Replicon: chromosome
• Accession: NZ_CP009678
• Organism: Pectobacterium odoriferum strain BC S7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BCS7_RS21235
• Protein ID: WP_080735445.1
• Coordinates: 4645453..4645728 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A094S1G3
• Locus tag: BCS7_RS21240
• Protein ID: WP_039491883.1
• Coordinates: 4645725..4646087 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCS7_RS21210	4640766..4641237	-	472	Protein_4066	hypothetical protein	-
BCS7_RS21215	4641428..4642360	+	933	WP_039491880.1	LysR family transcriptional regulator	-
BCS7_RS21220	4642488..4643858	-	1371	WP_039491881.1	envelope stress sensor histidine kinase CpxA	-
BCS7_RS21225	4643855..4644553	-	699	WP_010308725.1	envelope stress response regulator transcription factor CpxR	-
BCS7_RS21230	4644707..4645216	+	510	WP_039491882.1	cell-envelope stress modulator CpxP	-
BCS7_RS21235	4645453..4645728	+	276	WP_080735445.1	type II toxin-antitoxin system HicA family toxin	Toxin
BCS7_RS21240	4645725..4646087	+	363	WP_039491883.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BCS7_RS21245	4646347..4650090	+	3744	WP_103165163.1	DUF4132 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9977.51 Da
• Isoelectric Point: 10.9815

>T49399 WP_080735445.1 NZ_CP009678:4645453-4645728 [Pectobacterium odoriferum]
MQGKIASLRKKQRETLNQIFKTPALSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHHPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T49399 NZ_CP009678:4645453-4645728 [Pectobacterium odoriferum]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAACCAAATTTTCAAAACACCAGCACTTTCAGG
TGTTAAGTGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCATCCTCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13518.34 Da
• Isoelectric Point: 4.4969

>AT49399 WP_039491883.1 NZ_CP009678:4645725-4646087 [Pectobacterium odoriferum]
MTKALNTPNTMVISGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA

Nucleotide

• Length: 363 bp

>AT49399 NZ_CP009678:4645725-4646087 [Pectobacterium odoriferum]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTATTTCTGGACAACCGGCCATTATCAGTTACGTACCGGAAATGGG
TATGTTTCGTGGCAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTTGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGATTGACCATTGCGGCCGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A094S1G3