Detailed information of TA system TA049398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4609478..4610095
• Replicon: chromosome
• Accession: NZ_CP009678
• Organism: Pectobacterium odoriferum strain BC S7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C6DHN3
• Locus tag: BCS7_RS21060
• Protein ID: WP_010281507.1
• Coordinates: 4609478..4609657 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BCS7_RS21065
• Protein ID: WP_039491844.1
• Coordinates: 4609685..4610095 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCS7_RS21035	4604721..4605881	-	1161	WP_039491835.1	cystathionine gamma-synthase	-
BCS7_RS21040	4606069..4606386	+	318	WP_005973355.1	met regulon transcriptional regulator MetJ	-
BCS7_RS21045	4606604..4607401	+	798	WP_103160805.1	ABC transporter ATP-binding protein	-
BCS7_RS21050	4607443..4608372	+	930	WP_146619793.1	ABC transporter substrate-binding protein	-
BCS7_RS21055	4608369..4609378	+	1010	Protein_4035	iron chelate uptake ABC transporter family permease subunit	-
BCS7_RS21060	4609478..4609657	+	180	WP_010281507.1	type II toxin-antitoxin system HicA family toxin	Toxin
BCS7_RS21065	4609685..4610095	+	411	WP_039491844.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BCS7_RS21070	4610178..4610393	-	216	WP_010281510.1	50S ribosomal protein L31	-
BCS7_RS21075	4610688..4612886	+	2199	WP_103165164.1	primosomal protein N'	-
BCS7_RS22740	4612993..4613151	+	159	WP_158020517.1	hypothetical protein	-
BCS7_RS21080	4613174..4614217	+	1044	WP_039491848.1	DNA-binding transcriptional regulator CytR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6560.69 Da
• Isoelectric Point: 10.7838

>T49398 WP_010281507.1 NZ_CP009678:4609478-4609657 [Pectobacterium odoriferum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T49398 NZ_CP009678:4609478-4609657 [Pectobacterium odoriferum]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCTAGCAAACCGGGGTTAGTCACCATCCCGCACCCTAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCAGGAATATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14491.37 Da
• Isoelectric Point: 4.4227

>AT49398 WP_039491844.1 NZ_CP009678:4609685-4610095 [Pectobacterium odoriferum]
MFYPIAIEAGDETHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIGLLVEMGQDIPTVSSVGQLAKNTEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Nucleotide

• Length: 411 bp

>AT49398 NZ_CP009678:4609685-4610095 [Pectobacterium odoriferum]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGAGACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGGACTGTTGGTCGAAA
TGGGCCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTGGCAAAAAACACAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATCGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAATGTCACGCTGCCTAAGTCATTGATTGACCGTAT
TGATCGTTGTGTAGCGAGTAATCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCCCGATGA

Structures

Toxin

• AlphaFold DB: A0A7W2I1S0