Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1283074..1283699 Replicon chromosome
Accession NZ_CP009678
Organism Pectobacterium odoriferum strain BC S7

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag BCS7_RS05785 Protein ID WP_005976087.1
Coordinates 1283074..1283277 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag BCS7_RS05790 Protein ID WP_005976089.1
Coordinates 1283331..1283699 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCS7_RS05755 1278525..1278863 + 339 WP_002208627.1 P-II family nitrogen regulator -
BCS7_RS05760 1278897..1280189 + 1293 WP_103157874.1 ammonium transporter AmtB -
BCS7_RS05765 1280325..1281188 - 864 WP_103157873.1 acyl-CoA thioesterase II -
BCS7_RS05770 1281401..1281982 + 582 WP_039490514.1 YbaY family lipoprotein -
BCS7_RS05775 1282002..1282322 - 321 WP_015839360.1 MGMT family protein -
BCS7_RS05785 1283074..1283277 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
BCS7_RS05790 1283331..1283699 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
BCS7_RS05795 1284296..1284439 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
BCS7_RS05800 1284457..1284705 - 249 WP_039506474.1 type B 50S ribosomal protein L31 -
BCS7_RS05805 1284938..1288066 - 3129 WP_039490517.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T49395 WP_005976087.1 NZ_CP009678:c1283277-1283074 [Pectobacterium odoriferum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T49395 NZ_CP009678:c1283277-1283074 [Pectobacterium odoriferum]
ATGAAAAAAATAGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTTGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTAGCTGAACTGACAATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT49395 WP_005976089.1 NZ_CP009678:c1283699-1283331 [Pectobacterium odoriferum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT49395 NZ_CP009678:c1283699-1283331 [Pectobacterium odoriferum]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATCCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTTTTGTTTAGCAACTATGGCATTAATGATGCTGAACTACGGCGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGAGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References