Detailed information of TA system TA049391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 485344..486894
• Replicon: chromosome
• Accession: NZ_CP009678
• Organism: Pectobacterium odoriferum strain BC S7

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A094S2R4
• Locus tag: BCS7_RS02245
• Protein ID: WP_044206132.1
• Coordinates: 485596..486894 (+)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: BCS7_RS02240
• Protein ID: WP_039491637.1
• Coordinates: 485344..485592 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCS7_RS02220	481002..481793	+	792	WP_103157559.1	nucleotidyltransferase domain-containing protein	-
BCS7_RS02225	481832..483175	+	1344	WP_039491641.1	HEAT repeat domain-containing protein	-
BCS7_RS02230	483187..483978	-	792	WP_103164605.1	HNH endonuclease	-
BCS7_RS02235	484132..485229	+	1098	WP_039491638.1	DUF1615 domain-containing protein	-
BCS7_RS02240	485344..485592	+	249	WP_039491637.1	helix-turn-helix domain-containing protein	Antitoxin
BCS7_RS02245	485596..486894	+	1299	WP_044206132.1	type II toxin-antitoxin system HipA family toxin	Toxin
BCS7_RS02250	487031..488500	-	1470	WP_039491632.1	SulP family inorganic anion transporter	-
BCS7_RS02255	488497..489165	-	669	WP_072012979.1	carbonic anhydrase	-
BCS7_RS02260	489934..491883	-	1950	WP_039493903.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48418.51 Da
• Isoelectric Point: 7.4727

>T49391 WP_044206132.1 NZ_CP009678:485596-486894 [Pectobacterium odoriferum]
MNILTVALNGIAVGALAKGVGSDMTFTYYPDWLSRPGARAISLSLPLQRATYRGDVVYNFFDNLLPDNDSIRSRIQARFR
IATKQPFDLLTSIGGDCVGAIQIYPVDTPVAPVTDVHAEALDNDEIEALLQGYREAPLGMATDREDFRISLAGAQEKTAL
LWYKNQWHRPQGSTPTSHIFKLPIGYIANNSIDLSDSVENEWLCLKIAEKYGFTVAQAEISRFNSQKVLIVERFDRRWSR
SDKPWLMRLPQEDFCQALGIAPALKYESDGGPGIEKSMALLLGSQQAMQDRDAFFKSQILFWMLAAIDGHAKNFSVFIEP
GSAYRMTPLYDVISAFPFMGPAGISVQKAKMAMAVLGRNRHFHWHKILPRHYFSSARQVGYPQERVAAMMSEMKANTERV
IAEVEALLPNDFPERISYPIFAGLRSQAARLP

Nucleotide

• Length: 1299 bp

>T49391 NZ_CP009678:485596-486894 [Pectobacterium odoriferum]
ATGAATATTCTCACGGTGGCGCTTAATGGCATTGCCGTCGGGGCGCTAGCGAAGGGGGTAGGGAGCGATATGACGTTCAC
TTACTACCCTGATTGGCTGAGCCGTCCCGGTGCGCGCGCTATTTCTCTTTCATTGCCTCTACAGCGAGCCACCTATCGTG
GCGATGTGGTTTACAACTTCTTTGATAATTTATTACCTGACAACGACAGTATTCGCAGCAGGATTCAGGCTCGTTTTCGT
ATCGCGACGAAACAGCCCTTTGATTTACTGACTAGCATCGGTGGTGACTGCGTTGGTGCGATTCAGATCTATCCGGTCGA
TACACCTGTTGCACCTGTTACTGATGTACATGCAGAAGCGCTTGATAATGATGAGATTGAAGCGTTGCTGCAGGGTTATC
GGGAAGCGCCATTAGGGATGGCTACGGATCGTGAGGATTTTCGTATCTCTCTCGCCGGTGCGCAGGAAAAGACGGCGTTA
CTTTGGTATAAAAATCAGTGGCATCGTCCGCAGGGGAGTACGCCGACCAGCCATATTTTCAAATTACCGATTGGTTATAT
TGCCAACAACAGCATTGACCTCAGCGATAGTGTTGAAAACGAGTGGTTATGCCTGAAAATCGCCGAAAAGTATGGTTTTA
CGGTCGCTCAGGCGGAAATCTCCCGATTTAACTCACAAAAAGTCTTGATCGTTGAACGCTTTGATCGTCGCTGGTCACGC
AGCGATAAGCCTTGGCTGATGCGTTTACCACAGGAAGATTTTTGTCAGGCACTGGGTATTGCGCCGGCGTTAAAATACGA
GTCTGACGGTGGCCCCGGCATTGAGAAATCAATGGCGCTCTTGCTCGGTTCGCAACAGGCGATGCAGGATAGAGATGCCT
TTTTTAAAAGCCAGATACTGTTTTGGATGCTAGCCGCGATTGATGGTCATGCGAAAAATTTCAGCGTATTTATCGAACCA
GGCAGTGCATACCGTATGACGCCTTTATACGATGTGATATCCGCTTTTCCTTTCATGGGACCGGCAGGAATATCGGTCCA
GAAGGCGAAGATGGCGATGGCGGTTCTTGGGCGTAATCGTCATTTCCATTGGCATAAGATTTTGCCGCGGCACTATTTTT
CTAGCGCCAGACAAGTGGGCTATCCGCAGGAACGCGTTGCCGCAATGATGTCGGAGATGAAAGCGAATACGGAACGGGTC
ATTGCGGAGGTGGAGGCACTCCTTCCCAACGATTTTCCTGAACGTATCAGTTACCCTATTTTTGCGGGACTGCGATCGCA
GGCTGCTCGGCTTCCCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9332.57 Da
• Isoelectric Point: 6.4835

>AT49391 WP_039491637.1 NZ_CP009678:485344-485592 [Pectobacterium odoriferum]
MKITSAGMLAHAMRDERKKHKLNQSQVAESMGIKQSTVSDFENHPEGTRLETLFKLLAALDLELHLSKRGEPQAGQEWSE
EW

Nucleotide

• Length: 249 bp

>AT49391 NZ_CP009678:485344-485592 [Pectobacterium odoriferum]
ATGAAGATCACCTCTGCTGGCATGCTAGCCCATGCTATGCGCGATGAACGCAAAAAGCACAAACTGAATCAAAGCCAGGT
TGCCGAGAGTATGGGGATAAAGCAGTCCACGGTGTCTGATTTCGAGAATCACCCAGAAGGGACGCGGCTTGAAACATTGT
TCAAGCTGCTGGCGGCTCTGGATCTGGAACTTCATCTTTCCAAACGAGGGGAGCCACAAGCGGGTCAGGAATGGAGTGAG
GAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A094S2R4