Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 1058032..1059007 | Replicon | chromosome |
| Accession | NZ_CP009641 | ||
| Organism | Bacillus cereus 03BB108 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | C2NHW3 |
| Locus tag | AK40_RS09335 | Protein ID | WP_002002796.1 |
| Coordinates | 1058032..1058769 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | AK40_RS09340 | Protein ID | WP_000588712.1 |
| Coordinates | 1058882..1059007 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AK40_RS09310 | 1053524..1054225 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| AK40_RS09315 | 1054353..1055237 | + | 885 | WP_000795513.1 | hypothetical protein | - |
| AK40_RS09320 | 1055545..1056349 | - | 805 | Protein_1100 | alpha-keto acid decarboxylase family protein | - |
| AK40_RS09325 | 1056456..1056938 | + | 483 | WP_000191909.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| AK40_RS09330 | 1057106..1057843 | + | 738 | WP_000594157.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| AK40_RS09335 | 1058032..1058769 | + | 738 | WP_002002796.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| AK40_RS09340 | 1058882..1059007 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| AK40_RS09350 | 1059281..1059562 | - | 282 | WP_001041559.1 | hypothetical protein | - |
| AK40_RS09355 | 1059842..1060078 | - | 237 | WP_001021690.1 | hypothetical protein | - |
| AK40_RS33815 | 1060417..1060593 | + | 177 | WP_000852618.1 | hypothetical protein | - |
| AK40_RS09365 | 1060737..1062206 | + | 1470 | WP_000287551.1 | beta-Ala-His dipeptidase | - |
| AK40_RS09370 | 1062792..1063262 | - | 471 | WP_000771846.1 | DUF5065 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28283.98 Da Isoelectric Point: 8.2998
>T49350 WP_002002796.1 NZ_CP009641:1058032-1058769 [Bacillus cereus 03BB108]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T49350 NZ_CP009641:1058032-1058769 [Bacillus cereus 03BB108]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAGATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATGCAGCAGTATTTGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGGGCGAAGATT
GTTGTATTTGAAGCAGCAAAGGAATTAAATACAACCTTTCGCGGTATCCGCTCGCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTTATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAGATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATGCAGCAGTATTTGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGGGCGAAGATT
GTTGTATTTGAAGCAGCAAAGGAATTAAATACAACCTTTCGCGGTATCCGCTCGCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTTATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT49350 WP_000588712.1 NZ_CP009641:1058882-1059007 [Bacillus cereus 03BB108]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT49350 NZ_CP009641:1058882-1059007 [Bacillus cereus 03BB108]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
GTTACAGCAAGTAGAAGAGTTAGAAGAAGAGTTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
GTTACAGCAAGTAGAAGAGTTAGAAGAAGAGTTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D3YFM0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366GQT1 |