Detailed information of TA system TA049348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 581585..582243
• Replicon: chromosome
• Accession: NZ_CP009632
• Organism: Burkholderia vietnamiensis LMG 10929

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AK36_RS27610
• Protein ID: WP_011880197.1
• Coordinates: 581809..582243 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B4LJE8
• Locus tag: AK36_RS27605
• Protein ID: WP_043292778.1
• Coordinates: 581585..581812 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AK36_RS32120	577420..578128	-	709	Protein_547	cupin domain-containing protein	-
AK36_RS27590	578314..578721	-	408	WP_011880193.1	DUF934 domain-containing protein	-
AK36_RS27595	578718..580508	-	1791	WP_011880194.1	nitrite/sulfite reductase	-
AK36_RS32125	580642..580788	-	147	Protein_550	transposase	-
AK36_RS27605	581585..581812	+	228	WP_043292778.1	hypothetical protein	Antitoxin
AK36_RS27610	581809..582243	+	435	WP_011880197.1	PIN domain-containing protein	Toxin
AK36_RS27615	582658..583089	+	432	WP_011880199.1	hypothetical protein	-
AK36_RS27620	583086..583619	+	534	WP_011880200.1	RES family NAD+ phosphorylase	-
AK36_RS27625	584020..585003	+	984	WP_080938772.1	tyrosine-type recombinase/integrase	-
AK36_RS33450	585000..585383	+	384	WP_144410681.1	hypothetical protein	-
AK36_RS32135	585416..586233	+	818	WP_085954470.1	IS5-like element IS402 family transposase	-
AK36_RS27635	586283..586870	+	588	WP_080938773.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	578314..663132	84818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (3-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15721.10 Da
• Isoelectric Point: 7.2342

>T49348 WP_011880197.1 NZ_CP009632:581809-582243 [Burkholderia vietnamiensis LMG 10929]
VITYLLDVNVLIALLDPAHVQHEPAHAWFGRVGHSAWATCPLTENGVLRIIGNPKYPNTMVSPASVAPLVVQLRSHAGHT
FWSDDVSLLDEKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPNGGKHLELIP

Nucleotide

• Length: 435 bp

>T49348 NZ_CP009632:581809-582243 [Burkholderia vietnamiensis LMG 10929]
GTGATTACCTACCTTCTCGACGTCAACGTACTCATTGCTTTGCTCGACCCGGCACACGTTCAACACGAGCCGGCGCATGC
GTGGTTTGGCCGGGTAGGCCATTCCGCATGGGCCACGTGCCCGCTCACCGAGAACGGCGTGCTTCGAATTATCGGCAATC
CGAAATACCCGAATACGATGGTCTCTCCTGCATCCGTTGCACCGCTTGTTGTGCAACTGCGGTCCCATGCTGGGCACACA
TTCTGGTCGGACGATGTGAGCCTGCTCGACGAAAAACACGTCGACGCCACCCGTTTACTGTCCTCCGCTCAACTGACCGA
CACTTACCTCCTCGCGCTCGCTCGCGCACACAAAGGCAAGTTGGCGACCTTCGATCGCCGCTTGGTCGTCGACGCGGTTC
CGAACGGCGGGAAGCATCTTGAACTGATTCCTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8080.14 Da
• Isoelectric Point: 8.9793

>AT49348 WP_043292778.1 NZ_CP009632:581585-581812 [Burkholderia vietnamiensis LMG 10929]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRGTTNQSSRNGLPLMPVSATARPVTLDTVNQLRDDSL

Nucleotide

• Length: 228 bp

>AT49348 NZ_CP009632:581585-581812 [Burkholderia vietnamiensis LMG 10929]
ATGCGTACCACTATTGATATCGACGACGACGTCCTTGCCTTCGCGCGGGAGCGTGCAAAGCCCGGCACGAGTATCGGGAA
GGTCATTTCTGACCTCGCCCGTGCGGCCCTGCAGCGCGGAACAACGAACCAGTCGAGCCGAAACGGCTTGCCGTTGATGC
CGGTTTCCGCGACCGCCCGTCCGGTCACCCTTGATACCGTTAATCAACTTCGCGACGACTCGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4LJE8