Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 65036..65598 Replicon chromosome
Accession NZ_CP009632
Organism Burkholderia vietnamiensis LMG 10929

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B4LIX1
Locus tag AK36_RS25235 Protein ID WP_045579168.1
Coordinates 65036..65284 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B4LIN8
Locus tag AK36_RS25240 Protein ID WP_011879712.1
Coordinates 65278..65598 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK36_RS31905 60789..61232 + 444 WP_043292565.1 hypothetical protein -
AK36_RS31910 61233..61439 + 207 Protein_55 AraC family transcriptional regulator -
AK36_RS25210 61531..61931 + 401 Protein_56 arsenical pump-driving ATPase -
AK36_RS25215 61952..62363 + 412 Protein_57 DUF2703 domain-containing protein -
AK36_RS25220 62382..63491 + 1110 WP_011879708.1 NAD(P)/FAD-dependent oxidoreductase -
AK36_RS25235 65036..65284 + 249 WP_045579168.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
AK36_RS25240 65278..65598 + 321 WP_011879712.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AK36_RS33380 66126..66371 + 246 WP_131754457.1 hypothetical protein -
AK36_RS25245 66343..67233 + 891 WP_144410678.1 hypothetical protein -
AK36_RS25250 67275..67460 + 186 WP_043292729.1 hypothetical protein -
AK36_RS33385 67545..67736 + 192 WP_124259719.1 hypothetical protein -
AK36_RS25255 67907..68110 + 204 Protein_66 YhcG family protein -
AK36_RS25260 68420..69280 + 861 WP_045579531.1 transporter substrate-binding domain-containing protein -
AK36_RS25265 69373..70095 + 723 WP_011879718.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(9-44)

Antitoxin

mRNA interferase PemK-like

(4-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8979.19 Da        Isoelectric Point: 4.4929

>T49346 WP_045579168.1 NZ_CP009632:65036-65284 [Burkholderia vietnamiensis LMG 10929]
MKTTIRRMGNSQGVLIPKPVLAQLGLESEVEMEVENDAIVLRRPKHKAREGWAEASKALAESGDDALVMGEFSNADDAEL
AW

Download         Length: 249 bp

>T49346 NZ_CP009632:65036-65284 [Burkholderia vietnamiensis LMG 10929]
ATGAAGACGACGATTCGCAGAATGGGTAACTCGCAGGGCGTGCTGATTCCGAAGCCCGTCCTTGCGCAACTCGGGCTGGA
GAGCGAAGTGGAAATGGAGGTCGAGAACGACGCGATTGTTCTGCGCCGCCCGAAGCACAAAGCCCGTGAGGGGTGGGCGG
AAGCAAGCAAGGCTCTGGCCGAGAGCGGCGACGATGCGCTGGTTATGGGCGAGTTTTCGAACGCCGATGACGCGGAGCTT
GCATGGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11935.23 Da        Isoelectric Point: 10.5568

>AT49346 WP_011879712.1 NZ_CP009632:65278-65598 [Burkholderia vietnamiensis LMG 10929]
MVMRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPVPFRIPVTFKRKHGLILLDQIRAVDKVR
LVKKEGAVADKTLLDTLRTLQEVFAE

Download         Length: 321 bp

>AT49346 NZ_CP009632:65278-65598 [Burkholderia vietnamiensis LMG 10929]
ATGGTGATGCGCGGGGAAGTCTGGTTGGTCGCACTCGATCCGACGCTTGGTAGCGAGATTCAAAAGACGCGCCCCTGTGT
GGTCGTTTCACCTCCCGAAATGCACGACCACTTGCGCACTGTCATCGTCGCGCCGATGACTTCCAAGGGGCGTCCAGTGC
CGTTTCGGATTCCGGTTACGTTCAAGCGCAAACATGGTTTGATCCTTCTGGATCAGATTCGCGCAGTGGACAAGGTGCGC
TTGGTTAAGAAAGAGGGTGCAGTTGCCGATAAAACGTTGTTGGATACCCTGCGGACCTTGCAGGAAGTCTTTGCGGAATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LIX1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LIN8

References