Detailed information of TA system TA049344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 2630968..2631530
• Replicon: chromosome
• Accession: NZ_CP009631
• Organism: Burkholderia vietnamiensis LMG 10929

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: AK36_RS21855
• Protein ID: WP_045579167.1
• Coordinates: 2630968..2631288 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A1B4LIX1
• Locus tag: AK36_RS21860
• Protein ID: WP_045579168.1
• Coordinates: 2631282..2631530 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AK36_RS21835	2626778..2627062	-	285	WP_045579163.1	hypothetical protein	-
AK36_RS21840	2627126..2627587	-	462	WP_126221127.1	hypothetical protein	-
AK36_RS33225	2627635..2628081	-	447	WP_126221126.1	hypothetical protein	-
AK36_RS33230	2628095..2628394	-	300	WP_126221125.1	hypothetical protein	-
AK36_RS33235	2628679..2628876	-	198	WP_059889990.1	hypothetical protein	-
AK36_RS33240	2628914..2629156	-	243	WP_126221124.1	hypothetical protein	-
AK36_RS21850	2630127..2630369	-	243	WP_045579166.1	hypothetical protein	-
AK36_RS31555	2630727..2630957	-	231	WP_080938562.1	hypothetical protein	-
AK36_RS21855	2630968..2631288	-	321	WP_045579167.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AK36_RS21860	2631282..2631530	-	249	WP_045579168.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AK36_RS30310	2631656..2632327	-	672	WP_052691567.1	site-specific integrase	-
AK36_RS21870	2632491..2632817	+	327	WP_045579170.1	H-NS histone family protein	-
AK36_RS21875	2632948..2633739	+	792	WP_045579171.1	SOS response-associated peptidase family protein	-
AK36_RS21880	2633982..2634308	-	327	WP_045579172.1	hypothetical protein	-
AK36_RS21885	2634546..2635433	-	888	WP_045579173.1	ImmA/IrrE family metallo-endopeptidase	-
AK36_RS21890	2635437..2635784	-	348	WP_012367381.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-104)

Antitoxin

• SpoVT-AbrB domain (9-44)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11921.20 Da
• Isoelectric Point: 10.5568

>T49344 WP_045579167.1 NZ_CP009631:c2631288-2630968 [Burkholderia vietnamiensis LMG 10929]
MVMRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPAPFRIPVTFKRKHGLILLDQIRAVDKVR
LVKKEGAIADKTLLDTLRTLQEVFAE

Nucleotide

• Length: 321 bp

>T49344 NZ_CP009631:c2631288-2630968 [Burkholderia vietnamiensis LMG 10929]
ATGGTGATGCGCGGGGAAGTCTGGTTGGTCGCACTCGATCCGACGCTTGGTAGCGAGATTCAAAAGACGCGCCCCTGTGT
GGTCGTTTCACCTCCCGAAATGCACGACCACTTGCGCACAGTCATCGTCGCGCCGATGACTTCCAAGGGGCGTCCAGCGC
CGTTTCGGATTCCCGTGACGTTCAAGCGCAAACATGGTTTGATCCTTCTGGATCAGATTCGCGCAGTGGACAAGGTGCGC
CTGGTTAAGAAAGAGGGTGCAATTGCCGATAAAACGTTGTTGGATACCCTGCGGACCTTGCAGGAAGTCTTTGCGGAATA
G

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8979.19 Da
• Isoelectric Point: 4.4929

>AT49344 WP_045579168.1 NZ_CP009631:c2631530-2631282 [Burkholderia vietnamiensis LMG 10929]
MKTTIRRMGNSQGVLIPKPVLAQLGLESEVEMEVENDAIVLRRPKHKAREGWAEASKALAESGDDALVMGEFSNADDAEL
AW

Nucleotide

• Length: 249 bp

>AT49344 NZ_CP009631:c2631530-2631282 [Burkholderia vietnamiensis LMG 10929]
ATGAAGACGACGATTCGCAGAATGGGTAACTCGCAGGGCGTGCTGATTCCGAAGCCCGTCCTTGCGCAACTCGGGCTGGA
GAGCGAAGTGGAAATGGAGGTCGAGAACGACGCGATTGTTCTGCGCCGCCCGAAGCACAAAGCCCGTGAGGGGTGGGCGG
AAGCAAGCAAGGCTCTGGCCGAGAGCGGCGACGATGCGCTGGTTATGGGCGAGTTTTCGAACGCCGATGACGCGGAGCTT
GCATGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4LIX1