Detailed information of TA system TA049343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 664157..664794
• Replicon: chromosome
• Accession: NZ_CP009631
• Organism: Burkholderia vietnamiensis LMG 10929

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1G5N4H6
• Locus tag: AK36_RS13045
• Protein ID: WP_034192973.1
• Coordinates: 664157..664558 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: AK36_RS13050
• Protein ID: WP_045578624.1
• Coordinates: 664558..664794 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AK36_RS13035	661534..662670	+	1137	WP_045578623.1	alginate lyase family protein	-
AK36_RS13040	662701..664089	+	1389	WP_014722202.1	L-serine ammonia-lyase	-
AK36_RS13045	664157..664558	-	402	WP_034192973.1	type II toxin-antitoxin system VapC family toxin	Toxin
AK36_RS13050	664558..664794	-	237	WP_045578624.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AK36_RS13055	665073..666776	+	1704	WP_045578625.1	thiamine pyrophosphate-binding protein	-
AK36_RS13060	666773..667894	+	1122	WP_045578626.1	ADP-heptose--LPS heptosyltransferase	-
AK36_RS13065	668019..669053	-	1035	WP_034192975.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14848.01 Da
• Isoelectric Point: 5.1682

>T49343 WP_034192973.1 NZ_CP009631:c664558-664157 [Burkholderia vietnamiensis LMG 10929]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITCAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T49343 NZ_CP009631:c664558-664157 [Burkholderia vietnamiensis LMG 10929]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTGTGCCGAGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9022.15 Da
• Isoelectric Point: 5.7316

>AT49343 WP_045578624.1 NZ_CP009631:c664794-664558 [Burkholderia vietnamiensis LMG 10929]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLEKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT49343 NZ_CP009631:c664794-664558 [Burkholderia vietnamiensis LMG 10929]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGCGCATCGGCGACGAGATTCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTCGAGA
AGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA

Structures

Toxin

• AlphaFold DB: A0A1G5N4H6