Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 303091..304066 | Replicon | chromosome |
| Accession | NZ_CP009628 | ||
| Organism | Bacillus cereus ATCC 4342 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A7U6C7L7 |
| Locus tag | BF35_RS01675 | Protein ID | WP_002021399.1 |
| Coordinates | 303329..304066 (-) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A150BES9 |
| Locus tag | BF35_RS01670 | Protein ID | WP_000594607.1 |
| Coordinates | 303091..303216 (-) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BF35_RS01645 | 298139..298527 | - | 389 | Protein_300 | serine hydrolase | - |
| BF35_RS01650 | 299061..299720 | - | 660 | WP_000682537.1 | CatB-related O-acetyltransferase | - |
| BF35_RS01655 | 300175..300645 | + | 471 | Protein_302 | DUF5065 family protein | - |
| BF35_RS01660 | 301226..302695 | - | 1470 | WP_000287527.1 | beta-Ala-His dipeptidase | - |
| BF35_RS29335 | 302839..303015 | - | 177 | WP_000808046.1 | hypothetical protein | - |
| BF35_RS01670 | 303091..303216 | - | 126 | WP_000594607.1 | hypothetical protein | Antitoxin |
| BF35_RS01675 | 303329..304066 | - | 738 | WP_002021399.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| BF35_RS01680 | 304255..304992 | - | 738 | WP_000594142.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| BF35_RS01685 | 305160..305642 | - | 483 | WP_000191901.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| BF35_RS01690 | 305749..307434 | + | 1686 | WP_002021397.1 | alpha-keto acid decarboxylase family protein | - |
| BF35_RS01695 | 307556..308338 | - | 783 | WP_000381795.1 | class I SAM-dependent methyltransferase | - |
| BF35_RS01700 | 308624..309031 | - | 408 | WP_000072483.1 | VOC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28331.03 Da Isoelectric Point: 8.2638
>T49339 WP_002021399.1 NZ_CP009628:c304066-303329 [Bacillus cereus ATCC 4342]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T49339 NZ_CP009628:c304066-303329 [Bacillus cereus ATCC 4342]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT49339 WP_000594607.1 NZ_CP009628:c303216-303091 [Bacillus cereus ATCC 4342]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT49339 NZ_CP009628:c303216-303091 [Bacillus cereus ATCC 4342]
GTGATAAAAAATAATGATAATGATTTTTTTAAAGAAGACAATGAAGATACAACGGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
GTGATAAAAAATAATGATAATGATTTTTTTAAAGAAGACAATGAAGATACAACGGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U6C7L7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A150BES9 |