49332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1218459..1218983 Replicon chromosome
Accession NZ_CP009623
Organism Staphylococcus agnetis strain 908

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag EP23_RS18280 Protein ID WP_037567539.1
Coordinates 1218459..1218812 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A242VEK4
Locus tag EP23_RS18285 Protein ID WP_060551514.1
Coordinates 1218813..1218983 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP23_RS18260 1215761..1216531 - 771 WP_060551512.1 RNA polymerase sigma factor SigB -
EP23_RS18265 1216506..1216985 - 480 WP_037567547.1 anti-sigma B factor RsbW -
EP23_RS18270 1216988..1217314 - 327 WP_037567545.1 anti-sigma factor antagonist -
EP23_RS18275 1217395..1218399 - 1005 WP_060551513.1 PP2C family protein-serine/threonine phosphatase -
EP23_RS18280 1218459..1218812 - 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EP23_RS18285 1218813..1218983 - 171 WP_060551514.1 hypothetical protein Antitoxin
EP23_RS18290 1219068..1220216 - 1149 WP_060551515.1 alanine racemase -
EP23_RS18295 1220322..1220672 - 351 WP_060551516.1 holo-ACP synthase -
EP23_RS18300 1220744..1221250 - 507 WP_060551517.1 PH domain-containing protein -
EP23_RS18305 1221234..1222721 - 1488 WP_060551518.1 PH domain-containing protein -
EP23_RS18310 1222714..1223190 - 477 WP_060551519.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T49332 WP_037567539.1 NZ_CP009623:c1218812-1218459 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T49332 NZ_CP009623:c1218812-1218459 [Staphylococcus agnetis]
ATGAAACGTGGCGACGTTTATTTAGCAGATTTATCGCCAGTTCAAGGGTCGGAACAAGGGGGAGTCAGACCTGTCGTTAT
CATTCAAAATGATACTGGCAATAAGTATAGTCCAACGGTTATAGTAGCTGCAATTACTGGACGCATTAATAAAGCAAAAA
TTCCAACACATGTTGAAATTGAAAAACATAAATATAAGCTCGATAAAGATTCAGTTATCTTATTAGAACAAATAAGAACT
GTCGATAAAAAGAGACTTAAAGAAAAGTTGACATATCTTTCAGATAAAAAGATGAAAGAAGTGAACGCTGCACTTGGAAT
TAGTCTAGGATTGCACATGAACCAACATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6277.94 Da        Isoelectric Point: 4.0644

>AT49332 WP_060551514.1 NZ_CP009623:c1218983-1218813 [Staphylococcus agnetis]
MSAFYQIRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT49332 NZ_CP009623:c1218983-1218813 [Staphylococcus agnetis]
ATGTCAGCATTCTATCAAATAAGAGGTAAAAGCTTAGAACAATCATTAAAAGAAGGGTATGTTCAGATGGCGGATTTAAA
TCTCTCCCTAGCAACTGAAGCATACTCAGTCGAGTGTGAAGCTTGTGACTGTAACGAAACACACTTATTATCTAACAATA
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A242VEK4

References