Detailed information of TA system TA049331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1066773..1067546
• Replicon: chromosome
• Accession: NZ_CP009623
• Organism: Staphylococcus agnetis strain 908

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: EP23_RS17390
• Protein ID: WP_165804964.1
• Coordinates: 1066773..1066928 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A242VDN1
• Locus tag: EP23_RS17395
• Protein ID: WP_060551399.1
• Coordinates: 1066947..1067546 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP23_RS17375	1063123..1064649	-	1527	WP_060551396.1	exopolyphosphatase	-
EP23_RS17380	1064671..1066056	-	1386	WP_060551397.1	class II fumarate hydratase	-
EP23_RS17385	1066213..1066614	-	402	WP_060551398.1	hypothetical protein	-
EP23_RS17390	1066773..1066928	-	156	WP_165804964.1	hypothetical protein	Toxin
EP23_RS17395	1066947..1067546	-	600	WP_060551399.1	hypothetical protein	Antitoxin
EP23_RS17400	1067564..1068733	-	1170	WP_060551400.1	N-acetylglucosamine-6-phosphate deacetylase	-
EP23_RS17405	1068748..1069218	-	471	WP_060551401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EP23_RS17410	1069221..1070348	-	1128	WP_060551402.1	tRNA epoxyqueuosine(34) reductase QueG	-
EP23_RS17415	1070521..1071243	-	723	WP_060551403.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (135-197)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6027.40 Da
• Isoelectric Point: 3.9813

>T49331 WP_165804964.1 NZ_CP009623:c1066928-1066773 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPNIRSDQ

Nucleotide

• Length: 156 bp

>T49331 NZ_CP009623:c1066928-1066773 [Staphylococcus agnetis]
ATGTCTGATGAAAAGCATATTGAACATGAAAATGAAATGGTAGATAATTTCGAAGATCTCGTTCAATTAGGTAAAGAAAT
GGAACAGATTTCTGAGACAAATGATCAAGATAAAGTCAATCAATCACATGACCCGAATATTCGTTCAGATCAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22437.36 Da
• Isoelectric Point: 5.3398

>AT49331 WP_060551399.1 NZ_CP009623:c1067546-1066947 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVFDYLKHNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEQKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT49331 NZ_CP009623:c1067546-1066947 [Staphylococcus agnetis]
ATGGCAATGAACTTTAAAGTATTTAAAGACAAAGATACTGTAGCGGTTTATGCGGCAGATATCATTCGAAAACAATTTAA
TAATAATCCAACGACGATAGCAGGATTTCATCTTAGTGAAGAGGAAGCGCCTGTCTTTGACTATTTAAAACATAATGTTA
ACGACCATGCAGTTGATTTTAGTCAAATTCACATTTTAGATTATGATAAACAAGCGTCATATTTTAAGGCTCTTGGTGTA
CCTGAAAAACAAATTCATGAAATCCCAGAAGAAGACGAAGTAGAAAAATTCATTGAACAAAAAGCGAAAACGAAAGACAA
TAAAGGTAAACTTACATTACAAGTAGTGTCTATTAATAATAAAGGGGAATTTGGTGTCCCTGTTAATAATGGCTTAAAAC
CAGCACGCGAGATTTTTGTTGTTGTGACTGGAAGCGATAAAGCGGATGTGATTAAAAAATTATATGAGGATAATGGTAAT
ACGAGCTTTATTCCTTCTAGTTTGAAAACACACCGTATGGTGAATGTGATTCTTGATGAAGCTGCAGCTCAAGGATTACC
GGATGACGTAAGAGAATATTTCACTTCTCTTTATGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A242VDN1