Detailed information of TA system TA049329

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 256662..257211
• Replicon: plasmid p319
• Accession: NZ_CP009620
• Organism: Vibrio coralliilyticus strain RE98

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A2A2MR35
• Locus tag: IX92_RS28300
• Protein ID: WP_043011872.1
• Coordinates: 256662..256961 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A347UQT2
• Locus tag: IX92_RS28305
• Protein ID: WP_005442033.1
• Coordinates: 256969..257211 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IX92_RS28285	252303..254423	+	2121	WP_043011870.1	hypothetical protein	-
IX92_RS28290	254573..255028	-	456	WP_043011871.1	DUF1240 domain-containing protein	-
IX92_RS28295	255025..256191	-	1167	WP_043011962.1	hypothetical protein	-
IX92_RS29160	256517..256606	+	90	WP_080748955.1	DUF3265 domain-containing protein	-
IX92_RS28300	256662..256961	-	300	WP_043011872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IX92_RS28305	256969..257211	-	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IX92_RS28310	257487..257723	+	237	WP_021458677.1	hypothetical protein	-
IX92_RS28315	257882..258172	-	291	WP_043011873.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IX92_RS28320	258162..258410	-	249	WP_006958739.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IX92_RS29390	258467..258595	+	129	WP_144382900.1	DUF3265 domain-containing protein	-
IX92_RS28325	258741..259331	+	591	WP_043011874.1	Crp/Fnr family transcriptional regulator	-
IX92_RS28330	259393..259839	+	447	WP_043011875.1	isoprenylcysteine carboxylmethyltransferase family protein	-
IX92_RS28335	259961..260716	+	756	WP_043011876.1	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
IX92_RS28340	261116..262189	-	1074	WP_039951551.1	substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..319400	319400

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11439.05 Da
• Isoelectric Point: 9.3232

>T49329 WP_043011872.1 NZ_CP009620:c256961-256662 [Vibrio coralliilyticus]
MQKNKYKLSNLAQSHLHKIKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T49329 NZ_CP009620:c256961-256662 [Vibrio coralliilyticus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCACAAAATAAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACCCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGGCTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGACGGC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT49329 WP_005442033.1 NZ_CP009620:c257211-256969 [Vibrio coralliilyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT49329 NZ_CP009620:c257211-256969 [Vibrio coralliilyticus]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGCGAAAGCTTTCTGAACTCGCTG
TAA

Structures

Toxin

• AlphaFold DB: A0A2A2MR35

Antitoxin

• AlphaFold DB: A0A347UQT2