49328

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 193493..194852 Replicon plasmid p319
Accession NZ_CP009620
Organism Vibrio coralliilyticus strain RE98

Toxin (Protein)


Gene name sanaT Uniprot ID A0A7Y3YXA3
Locus tag IX92_RS28005 Protein ID WP_043011804.1
Coordinates 193493..194446 (-) Length 318 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A7Y3YZB2
Locus tag IX92_RS28010 Protein ID WP_043011806.1
Coordinates 194448..194852 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IX92_RS28000 191660..193111 + 1452 WP_043011803.1 phospholipase -
IX92_RS28005 193493..194446 - 954 WP_043011804.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IX92_RS28010 194448..194852 - 405 WP_043011806.1 hypothetical protein Antitoxin
IX92_RS28015 195140..196420 - 1281 WP_043011807.1 membrane protein -
IX92_RS28020 196600..197100 + 501 WP_043011945.1 DUF1993 family protein -
IX92_RS29525 197114..197458 + 345 WP_162473593.1 hypothetical protein -
IX92_RS28025 197473..198261 - 789 WP_043011809.1 hypothetical protein -
IX92_RS28030 198393..199142 - 750 WP_043011811.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..319400 319400


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-301)

Antitoxin

Protein of unknown function DUF6088

(9-130)


Sequences

Toxin        


Download         Length: 318 a.a.        Molecular weight: 36746.56 Da        Isoelectric Point: 5.7229

>T49328 WP_043011804.1 NZ_CP009620:c194446-193493 [Vibrio coralliilyticus]
MEKLKQQFLEVSDALELGNPAIIEKDYWVVALLAELTKVSPMHHQMVFSGGTALAKSNIKILRMSEDVDIKLIPKPAFSE
LSRAKKKATRKICMNEIEQTITQSEHFTIEARIVRDEYRYVELELRYPQQFSQAPCLRPIVKLELIETIPLIDVEARSIQ
SLVSELYKQPQEVEVFDCVSIDATLVEKVISMLRRTMSVKRNAQRKDDATLVRHIYDVYCILKTEGQTDHLDLKTLTPLF
KKVLEEDVERFGNQHAEFVSNPKQELELGLKELEENPVFRQRFQDFVTPMVFNSEPHDFDICFVSFKRVAESLIKTI

Download         Length: 954 bp

>T49328 NZ_CP009620:c194446-193493 [Vibrio coralliilyticus]
ATGGAAAAATTAAAACAACAATTTCTTGAGGTTTCCGATGCACTTGAGCTCGGAAACCCCGCCATTATTGAAAAAGATTA
CTGGGTCGTCGCTTTACTTGCAGAATTGACGAAAGTGTCGCCAATGCATCATCAAATGGTCTTTTCTGGCGGGACTGCTC
TAGCAAAGTCCAACATTAAAATTCTTAGGATGTCAGAAGACGTAGACATTAAACTGATTCCGAAACCAGCGTTTAGTGAA
CTAAGTCGTGCCAAAAAGAAAGCGACTCGTAAGATCTGCATGAACGAGATTGAGCAGACGATAACTCAGTCAGAGCATTT
CACAATTGAGGCGCGAATTGTTCGTGATGAGTATCGCTATGTTGAACTCGAGCTCAGGTACCCTCAGCAGTTTAGTCAAG
CACCATGTCTTCGCCCCATTGTTAAGCTGGAATTGATAGAGACTATTCCACTAATCGATGTAGAAGCTCGCAGCATTCAA
TCATTGGTTTCGGAGCTATATAAACAACCACAAGAAGTGGAGGTGTTTGATTGCGTCTCTATCGATGCAACCTTGGTTGA
AAAAGTGATTTCAATGTTGCGCCGTACCATGTCAGTTAAGCGCAATGCGCAGCGTAAGGATGATGCCACCCTAGTGCGAC
ATATCTATGATGTTTACTGCATTTTGAAAACCGAGGGACAGACTGATCACCTCGATCTGAAAACACTAACACCGTTGTTT
AAAAAGGTGTTGGAAGAAGACGTTGAGCGTTTTGGTAATCAGCATGCAGAGTTCGTATCCAATCCTAAACAAGAGCTAGA
ACTCGGGCTGAAAGAGCTTGAAGAAAATCCAGTCTTTCGACAGCGCTTTCAAGACTTTGTTACCCCTATGGTGTTTAACA
GCGAGCCTCATGATTTTGATATCTGCTTTGTTTCCTTCAAACGCGTAGCAGAGTCGCTAATTAAAACAATATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15210.51 Da        Isoelectric Point: 10.7167

>AT49328 WP_043011806.1 NZ_CP009620:c194852-194448 [Vibrio coralliilyticus]
MTAVDRVYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVKQGELIKLGYGLYTKARINSLTGRPMPTNPGGSDALMRE
ILKMKGVDFEMDSLSLQSLSGESTQIPSSVQYSWNPKQFNRKLAVGKRVLNSPS

Download         Length: 405 bp

>AT49328 NZ_CP009620:c194852-194448 [Vibrio coralliilyticus]
ATGACAGCTGTTGATCGTGTTTATCAGAAGATTAAGCGTTCGAGACGCTATGTTTTTGAGCGCAAAGACTTTGATGGCTT
TGCTAGCTACGATCAAATTGGTCGAGCATTAAGGCAACTGGTTAAGCAAGGCGAGTTAATAAAACTTGGCTATGGACTGT
ATACCAAAGCCCGCATTAACAGCCTAACCGGGAGGCCTATGCCCACGAACCCGGGTGGAAGTGATGCCCTAATGCGTGAG
ATATTAAAGATGAAAGGCGTCGATTTTGAAATGGACAGCCTATCTTTGCAAAGCTTATCAGGAGAAAGTACCCAAATCCC
ATCCTCCGTTCAATACTCATGGAACCCCAAACAATTTAATCGCAAATTGGCTGTTGGTAAGCGAGTATTAAACTCGCCGA
GTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3YXA3

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3YZB2

References