Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1705730..1706342 Replicon chromosome
Accession NZ_CP009612
Organism Streptococcus pyogenes strain HKU360

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag HKU360_RS08550 Protein ID WP_002988077.1
Coordinates 1706007..1706342 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag HKU360_RS08545 Protein ID WP_002988079.1
Coordinates 1705730..1706017 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKU360_RS08520 1700921..1701904 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
HKU360_RS08525 1701908..1702837 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
HKU360_RS08530 1702883..1703398 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
HKU360_RS08535 1703433..1703861 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
HKU360_RS08540 1704307..1705080 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
HKU360_RS08545 1705730..1706017 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
HKU360_RS08550 1706007..1706342 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKU360_RS10360 1706494..1706964 + 471 WP_002988074.1 integrase -
HKU360_RS10365 1706927..1707289 + 363 WP_180373113.1 tyrosine-type recombinase/integrase -
HKU360_RS10370 1707325..1707474 + 150 WP_002982720.1 hypothetical protein -
HKU360_RS08560 1707594..1707986 - 393 WP_002982716.1 30S ribosomal protein S9 -
HKU360_RS08565 1708007..1708453 - 447 WP_002982710.1 50S ribosomal protein L13 -
HKU360_RS08570 1708671..1708877 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
HKU360_RS08575 1708874..1709380 - 507 WP_002988070.1 hypothetical protein -
HKU360_RS08580 1709516..1710376 - 861 WP_002982687.1 DegV family protein -
HKU360_RS08585 1710473..1710991 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T49326 WP_002988077.1 NZ_CP009612:1706007-1706342 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T49326 NZ_CP009612:1706007-1706342 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT49326 WP_002988079.1 NZ_CP009612:1705730-1706017 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT49326 NZ_CP009612:1705730-1706017 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References