Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1613644..1614233 Replicon chromosome
Accession NZ_CP009610
Organism Haemophilus influenzae strain Hi375

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag NF38_RS07880 Protein ID WP_005653200.1
Coordinates 1613985..1614233 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag NF38_RS07875 Protein ID WP_005653201.1
Coordinates 1613644..1613988 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF38_RS07860 1608867..1610261 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
NF38_RS07865 1610305..1610919 + 615 WP_005657019.1 riboflavin synthase -
NF38_RS07870 1610991..1613600 - 2610 WP_011272463.1 aminopeptidase N -
NF38_RS07875 1613644..1613988 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NF38_RS07880 1613985..1614233 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
NF38_RS07885 1614404..1614898 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
NF38_RS07890 1614968..1616056 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
NF38_RS07895 1616196..1617386 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
NF38_RS07900 1617493..1618119 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
NF38_RS07905 1618121..1618753 - 633 WP_038441311.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T49325 WP_005653200.1 NZ_CP009610:c1614233-1613985 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T49325 NZ_CP009610:c1614233-1613985 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT49325 WP_005653201.1 NZ_CP009610:c1613988-1613644 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT49325 NZ_CP009610:c1613988-1613644 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References