49321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 572041..572519 Replicon chromosome
Accession NZ_CP009610
Organism Haemophilus influenzae strain Hi375

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag NF38_RS02815 Protein ID WP_011272058.1
Coordinates 572241..572519 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag NF38_RS02810 Protein ID WP_038440584.1
Coordinates 572041..572232 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF38_RS02790 568251..569234 + 984 WP_038440579.1 DNA polymerase III subunit delta' -
NF38_RS02795 569287..570069 + 783 WP_038440581.1 YchF/TatD family DNA exonuclease -
NF38_RS02800 570096..570620 + 525 WP_038440582.1 DUF1523 family protein -
NF38_RS02805 570671..571969 + 1299 WP_005691371.1 hemolysin family protein -
NF38_RS02810 572041..572232 + 192 WP_038440584.1 DUF5397 family protein Antitoxin
NF38_RS02815 572241..572519 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
NF38_RS02820 572612..573142 + 531 WP_038440586.1 hypothetical protein -
NF38_RS02825 573214..574713 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
NF38_RS02830 574715..575656 + 942 WP_011272055.1 1-phosphofructokinase -
NF38_RS02835 575658..577328 + 1671 WP_011272054.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T49321 WP_011272058.1 NZ_CP009610:572241-572519 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T49321 NZ_CP009610:572241-572519 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7113.08 Da        Isoelectric Point: 3.9930

>AT49321 WP_038440584.1 NZ_CP009610:572041-572232 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVHYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT49321 NZ_CP009610:572041-572232 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCATTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure

References